拼音注音 : Zhū Tí Jiǎ
別名 : 豬(zhu)(zhu)懸蹄（《本經》），豬(zhu)(zhu)懸蹄甲（《千金·食治》），豬(zhu)(zhu)蹄合子（《圣濟總錄》），豬(zhu)(zhu)爪甲（《普濟方(fang)》），豬(zhu)(zhu)退（《綱目》）。
出處 : 《綱目》
來源 : 為豬科動物豬的蹄甲。
原形態 : 動(dong)物形態詳"豬肉"條。
炮制 : 《千金·食治》："酒浸半日，炙焦(jiao)用(yong)之。"
歸經 : 《本草經(jing)(jing)疏》："入手、足(zu)陽明經(jing)(jing)。"
性味 : 咸，平(ping)(ping)。①《本經》："平(ping)(ping)。"②《藥對》："微寒。"③《綱目》："咸，平(ping)(ping)，無毒。"
功能主治 : 治咳嗽喘息(xi)，痔瘡(chuang)；白禿，凍瘡(chuang)。①《本經》："主(zhu)五痔，伏熱在腸，腸癰(yong)內(nei)蝕。"②《本經逢原》："治目疾(ji)外障。"
用法用量 : 內服(fu)：燒灰(hui)研(yan)末。外用：研(yan)末調敷。
復方 : ①治(zhi)(zhi)(zhi)久(jiu)咳嗽喘(chuan)息(xi)：豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)蹄(ti)(ti)合(he)子四十九(jiu)枚(mei)(mei)（黑者(zhe)，水(shui)浸洗凈），天(tian)南星(xing)一(yi)(yi)枚(mei)(mei)（大(da)者(zhe)銼），款冬花（帶蕊者(zhe)末）半兩。上(shang)三昧(mei)，用瓶子一(yi)(yi)枚(mei)(mei)，鋪豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)蹄(ti)(ti)合(he)子在內，上(shang)以(yi)(yi)天(tian)南星(xing)勻蓋之，合(he)了，鹽泥赤石脂(zhi)固濟(ji)火煅，白(bai)煙(yan)出為度，候(hou)冷(leng)取出，入(ru)(ru)款冬花末并麝香一(yi)(yi)分，龍腦少許，同研(yan)(yan)(yan)。每(mei)服(fu)一(yi)(yi)錢匕，食后(hou)煎桑根白(bai)皮湯(tang)調(diao)下。（《圣濟(ji)總(zong)錄(lu)》黑金散）②治(zhi)(zhi)(zhi)諸痔(zhi)：豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)懸(xuan)(xuan)蹄(ti)(ti)甲不(bu)拘多少，燒(shao)存性(xing)(xing)，為末，陳米湯(tang)調(diao)二(er)鈸，空心(xin)服(fu)。（《仁齋直(zhi)指方(fang)》豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)甲散）③治(zhi)(zhi)(zhi)牡痔(zhi)生鼠乳，肛門癢痛，觸(chu)著有膿血(xue)出不(bu)絕：豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)懸(xuan)(xuan)蹄(ti)(ti)殼(ke)(ke)（燒(shao)成灰、研(yan)(yan)(yan)）一(yi)(yi)兩，水(shui)銀三大(da)豆許。上(shang)二(er)味，先(xian)取水(shui)銀，用蒸棗(zao)肉(rou)二(er)枚(mei)(mei)，研(yan)(yan)(yan)勻，次入(ru)(ru)蹄(ti)(ti)殼(ke)(ke)灰，拌(ban)和(he)(he)為丸(wan)，如雞頭實(shi)大(da)。先(xian)以(yi)(yi)鹽湯(tang)洗下部，納(na)一(yi)(yi)丸(wan)，夜臥時再用，以(yi)(yi)瘥為度。（《圣濟(ji)總(zong)錄(lu)》豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)蹄(ti)(ti)灰丸(wan)）④治(zhi)(zhi)(zhi)小兒(er)白(bai)禿：豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)蹄(ti)(ti)甲七個，每(mei)個入(ru)(ru)白(bai)礬一(yi)(yi)塊，棗(zao)兒(er)一(yi)(yi)個，燒(shao)存性(xing)(xing)，研(yan)(yan)(yan)末，入(ru)(ru)輕粉(fen)、麻(ma)油調(diao)搽。（《綱目》）⑤治(zhi)(zhi)(zhi)凍爛瘡：豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)后(hou)懸(xuan)(xuan)蹄(ti)(ti)一(yi)(yi)味，燒(shao)為灰，研(yan)(yan)(yan)細，以(yi)(yi)豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)脂(zhi)和(he)(he)敷(fu)之。（《圣濟(ji)總(zong)錄(lu)》豬(zhu)(zhu)(zhu)(zhu)(zhu)(zhu)蹄(ti)(ti)膏(gao)）
摘錄 : 《中藥(yao)大辭典》
拼音注音 : Zhū Tí Jiǎ
別名 : 豬(zhu)(zhu)懸蹄、豬(zhu)(zhu)懸蹄甲(jia)、豬(zhu)(zhu)蹄合(he)子、豬(zhu)(zhu)爪甲(jia)、豬(zhu)(zhu)退(tui)
英文名 : Pig's toenail
出處 : 出自《本草綱(gang)目》
來源 : 藥材基源(yuan)：為豬科(ke)動物(wu)豬的(de)蹄甲。拉丁植物(wu)動物(wu)礦物(wu)名：Sus scrofa domestica Brisson采收和儲藏：宰殺(sha)后，刮去豬毛，剁下蹄甲，洗凈晾干(gan)。
生境分布 : 生(sheng)態(tai)環境：雜(za)食(shi)性家養(yang)物畜，繁(fan)殖力強，孕(yun)期約4個月。資源分布(bu)：全國各地均有(you)飼養(yang)。
原形態 : 豬的品種繁多，達150多種，形態(tai)也有(you)(you)差異基本特(te)微是(shi)：軀體肥胖，頭大。鼻與口吻(wen)皆長略向上屈。眼小(xiao)。耳殼有(you)(you)的大而下(xia)垂，有(you)(you)的較小(xiao)而前挺。四肢短小(xiao)，4趾(zhi)，前2趾(zhi)有(you)(you)蹄(ti)，后2趾(zhi)有(you)(you)懸蹄(ti)。頸粗(cu)，項背(bei)疏生(sheng)鬃毛(mao)。尾短小(xiao)，末端有(you)(you)毛(mao)叢。毛(mao)色有(you)(you)純黑、純白(bai)或黑白(bai)混雜等。
性狀 : 性(xing)狀(zhuang)(zhuang)鑒別 本品呈(cheng)三(san)(san)角(jiao)(jiao)(jiao)(jiao)錐(zhui)體(ti)狀(zhuang)(zhuang)或(huo)鞋頭狀(zhuang)(zhuang)，有時兩(liang)(liang)(liang)個(ge)相連，底(di)部(bu)較平坦，呈(cheng)三(san)(san)角(jiao)(jiao)(jiao)(jiao)形(xing)(xing)；長(chang)4-10.5cm，高3-3.5cm；蹄(ti)(ti)壁(bi)(bi)厚(hou)(hou)薄不一(yi)，蹄(ti)(ti)尖部(bu)（蹄(ti)(ti)關壁(bi)(bi)）最厚(hou)(hou)，3-4mm，向(xiang)(xiang)后(hou)方漸薄，蹄(ti)(ti)后(hou)部(bu)（蹄(ti)(ti)題壁(bi)(bi)和(he)蹄(ti)(ti)側壁(bi)(bi)）厚(hou)(hou)約2mm左右，蹄(ti)(ti)線(xian)(xian)處最薄，呈(cheng)薄膜(mo)狀(zhuang)(zhuang)， 0.10-0.25mm。黃白色或(huo)黑褐色。外表(biao)面(mian)平滑或(huo)粗(cu)糙，有光澤，蹄(ti)(ti)甲尖部(bu)上倒(dao)具(ju)(ju)角(jiao)(jiao)(jiao)(jiao)質(zhi)(zhi)輪(lun)紋(wen)(wen)(wen)(wen)和(he)細(xi)密(mi)(mi)縱(zong)(zong)線(xian)(xian)紋(wen)(wen)(wen)(wen)，老者用質(zhi)(zhi)輪(lun)紋(wen)(wen)(wen)(wen)呈(cheng)開(kai)裂狀(zhuang)(zhuang)；后(hou)端(duan)(duan)具(ju)(ju)細(xi)密(mi)(mi)縱(zong)(zong)條(tiao)線(xian)(xian)紋(wen)(wen)(wen)(wen)，周邊(bian)蹄(ti)(ti)練外翻或(huo)內卷，可見毛孔及殘(can)留豬毛。蹄(ti)(ti)底(di)部(bu)呈(cheng)圓三(san)(san)角(jiao)(jiao)(jiao)(jiao)形(xing)(xing)，前端(duan)(duan)為三(san)(san)角(jiao)(jiao)(jiao)(jiao)形(xing)(xing)的(de)(de)角(jiao)(jiao)(jiao)(jiao)質(zhi)(zhi)底(di)，較平坦，蹄(ti)(ti)底(di)邊(bian)緣(yuan)(yuan)寬(kuan)1-4.2mm，由蹄(ti)(ti)壁(bi)(bi)及蹄(ti)(ti)白線(xian)(xian)兩(liang)(liang)(liang)部(bu)分構(gou)成(cheng)，其上可見密(mi)(mi)集(ji)(ji)突起(qi)的(de)(de)角(jiao)(jiao)(jiao)(jiao)小(xiao)(xiao)(xiao)葉(xie)(xie)(xie)條(tiao)紋(wen)(wen)(wen)(wen)；后(hou)端(duan)(duan)為半橢圓形(xing)(xing)的(de)(de)角(jiao)(jiao)(jiao)(jiao)質(zhi)(zhi)球，具(ju)(ju)皺紋(wen)(wen)(wen)(wen)及密(mi)(mi)集(ji)(ji)凸起(qi)小(xiao)(xiao)(xiao)點。內表(biao)面(mian)上部(bu)前端(duan)(duan)及兩(liang)(liang)(liang)側壁(bi)(bi)具(ju)(ju)密(mi)(mi)集(ji)(ji)縱(zong)(zong)向(xiang)(xiang)排(pai)(pai)列(lie)(lie)的(de)(de)用小(xiao)(xiao)(xiao)葉(xie)(xie)(xie)，用小(xiao)(xiao)(xiao)葉(xie)(xie)(xie)寬(kuan)1.2-2.3mm；蹄(ti)(ti)底(di)部(bu)具(ju)(ju)密(mi)(mi)集(ji)(ji)圓點狀(zhuang)(zhuang)凹(ao)陷及條(tiao)狀(zhuang)(zhuang)血絲斑紋(wen)(wen)(wen)(wen)。角(jiao)(jiao)(jiao)(jiao)質(zhi)(zhi)，半透明或(huo)微透明狀(zhuang)(zhuang)，質(zhi)(zhi)堅韌，不易折(zhe)斷，折(zhe)斷面(mian)不整齊(qi)，斷面(mian)顯角(jiao)(jiao)(jiao)(jiao)質(zhi)(zhi)樣光澤或(huo)纖(xian)維性(xing)；氣腥，味(wei)成(cheng)。顯微鑒別 蹄(ti)(ti)尖壁(bi)(bi)由外、中(zhong)、內三(san)(san)層(ceng)(ceng)結構(gou)組成(cheng)。縱(zong)(zong)切面(mian)觀，外層(ceng)(ceng)為釉層(ceng)(ceng)，由角(jiao)(jiao)(jiao)(jiao)化的(de)(de)扁(bian)平細(xi)胞構(gou)成(cheng)，幼(you)蹄(ti)(ti)甲明顯，老蹄(ti)(ti)甲多(duo)脫落；中(zhong)層(ceng)(ceng)為冠狀(zhuang)(zhuang)層(ceng)(ceng)，是最厚(hou)(hou)的(de)(de)一(yi)層(ceng)(ceng)，由平行(xing)排(pai)(pai)列(lie)(lie)的(de)(de)角(jiao)(jiao)(jiao)(jiao)小(xiao)(xiao)(xiao)管(guan)構(gou)成(cheng)；內層(ceng)(ceng)為小(xiao)(xiao)(xiao)葉(xie)(xie)(xie)層(ceng)(ceng)，由許(xu)多(duo)平行(xing)排(pai)(pai)列(lie)(lie)的(de)(de)角(jiao)(jiao)(jiao)(jiao)小(xiao)(xiao)(xiao)葉(xie)(xie)(xie)構(gou)成(cheng)。表(biao)面(mian)觀，小(xiao)(xiao)(xiao)葉(xie)(xie)(xie)呈(cheng)長(chang)方形(xing)(xing)薄片(pian)狀(zhuang)(zhuang)，柔(rou)韌，邊(bian)緣(yuan)(yuan)齒狀(zhuang)(zhuang)，常翻卷，兩(liang)(liang)(liang)小(xiao)(xiao)(xiao)葉(xie)(xie)(xie)間具(ju)(ju)空隙（為肉小(xiao)(xiao)(xiao)葉(xie)(xie)(xie)嵌分處），縱(zong)(zong)向(xiang)(xiang)平行(xing)排(pai)(pai)列(lie)(lie)。蹄(ti)(ti)踵壁(bi)(bi)表(biao)面(mian)觀具(ju)(ju)縱(zong)(zong)向(xiang)(xiang)平行(xing)排(pai)(pai)列(lie)(lie)的(de)(de)角(jiao)(jiao)(jiao)(jiao)小(xiao)(xiao)(xiao)管(guan)及管(guan)問角(jiao)(jiao)(jiao)(jiao)質(zhi)(zhi)。用小(xiao)(xiao)(xiao)管(guan)細(xi)長(chang)錐(zhui)體(ti)形(xing)(xing)，長(chang)168-840μm，直徑(jing)70-98μm；頂端(duan)(duan)鈍關，基部(bu)斜向(xiang)(xiang)開(kai)口，呈(cheng)類圓形(xing)(xing)式(shi)長(chang)圓形(xing)(xing)；多(duo)單個(ge)或(huo)兩(liang)(liang)(liang)個(ge)并列(lie)(lie)，呈(cheng)縱(zong)(zong)向(xiang)(xiang)交錯排(pai)(pai)列(lie)(lie)；管(guan)間角(jiao)(jiao)(jiao)(jiao)質(zhi)(zhi)相間其中(zhong)。蹄(ti)(ti)球內表(biao)面(mian)觀具(ju)(ju)眾多(duo)共(gong)圓形(xing)(xing)凹(ao)陷小(xiao)(xiao)(xiao)孔，大小(xiao)(xiao)(xiao)不一(yi)，直徑(jing)44-560μm，由不規(gui)則的(de)(de)角(jiao)(jiao)(jiao)(jiao)化細(xi)胞構(gou)成(cheng)，呈(cheng)黑洞狀(zhuang)(zhuang)。
藥理作用 : 1.對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)液(ye)系(xi)統的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)散(san)(san)或(huo)(huo)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)（堿(jian)(jian)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)提取物(wu)）外(wai)散(san)(san)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)犬。兔(tu)(tu)(tu)(tu)(tu)等動(dong)物(wu)耳、肝(gan)、脾或(huo)(huo)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)管(guan)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)切口有(you)(you)(you)(you)(you)(you)(you)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，其(qi)(qi)(qi)止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)時(shi)間(jian)(jian)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)短(duan)(duan)于(yu)(yu)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)照組(zu)(zu)或(huo)(huo)其(qi)(qi)(qi)他止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)散(san)(san)。在(zai)(zai)(zai)(zai)(zai)前(qian)(qian)列腺(xian)摘(zhai)(zhai)除術(shu)中(zhong)使(shi)(shi)(shi)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)散(san)(san)，使(shi)(shi)(shi)失(shi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)量(liang)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)減(jian)(jian)(jian)少(shao)(shao)（P＜0.01）。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)500mg/kg，腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，濾紙法(fa)測(ce)定(ding)(ding)(ding)(ding)，顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)縮(suo)(suo)短(duan)(duan)免(mian)出血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)時(shi)間(jian)(jian)，玻片(pian)法(fa)測(ce)定(ding)(ding)(ding)(ding)能(neng)(neng)(neng)(neng)(neng)(neng)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)縮(suo)(suo)短(duan)(duan)家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)時(shi)間(jian)(jian)和(he)(he)(he)(he)(he)(he)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)漿復鈣(gai)(gai)時(shi)間(jian)(jian)，失(shi)明(ming)(ming)(ming)(ming)(ming)(ming)有(you)(you)(you)(you)(you)(you)(you)促(cu)進凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)；但(dan)(dan)(dan)體(ti)(ti)(ti)外(wai)不(bu)(bu)能(neng)(neng)(neng)(neng)(neng)(neng)縮(suo)(suo)短(duan)(duan)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)漿復鈣(gai)(gai)時(shi)間(jian)(jian)，提示(shi)體(ti)(ti)(ti)外(wai)無(wu)(wu)(wu)促(cu)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)500mg/kg靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，毛(mao)(mao)細(xi)(xi)(xi)(xi)(xi)(xi)管(guan)法(fa)測(ce)定(ding)(ding)(ding)(ding)，也(ye)(ye)能(neng)(neng)(neng)(neng)(neng)(neng)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)縮(suo)(suo)短(duan)(duan)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)時(shi)間(jian)(jian)。另有(you)(you)(you)(you)(you)(you)(you)報(bao)道(dao)，宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)，小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)海田(tian)(tian)(tian)灌胃(wei)10%溶(rong)液(ye)1ml，48h后(hou)(hou)(hou)測(ce)，凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)時(shi)間(jian)(jian)也(ye)(ye)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)縮(suo)(suo)短(duan)(duan)。豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)堿(jian)(jian)提取物(wu)500mg/kg腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，沈氏(shi)法(fa)測(ce)定(ding)(ding)(ding)(ding)能(neng)(neng)(neng)(neng)(neng)(neng)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)縮(suo)(suo)短(duan)(duan)家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)酶(mei)原(yuan)時(shi)間(jian)(jian)，但(dan)(dan)(dan)正(zheng)(zheng)常(chang)(chang)(chang)家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)紅素(su)(su)(su)(su)(su)可(ke)(ke)(ke)(ke)使(shi)(shi)(shi)堿(jian)(jian)提物(wu)組(zu)(zu)家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)酶(mei)原(yuan)時(shi)間(jian)(jian)恢復到鹽(yan)水(shui)組(zu)(zu)水(shui)平，提示(shi)堿(jian)(jian)提物(wu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)促(cu)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，與(yu)(yu)(yu)(yu)(yu)激(ji)(ji)(ji)(ji)活(huo)(huo)(huo)內(nei)(nei)源性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)系(xi)統有(you)(you)(you)(you)(you)(you)(you)關(guan)(guan)(guan)(guan)。同(tong)上(shang)(shang)(shang)劑(ji)(ji)量(liang)腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，使(shi)(shi)(shi)家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)心(xin)臟(zang)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)液(ye)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)優球(qiu)蛋(dan)(dan)白時(shi)間(jian)(jian)（ELT）明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)延長(chang)，因(yin)而(er)纖(xian)溶(rong)活(huo)(huo)(huo)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)降(jiang)(jiang)低(di)。問上(shang)(shang)(shang)劑(ji)(ji)量(liang)，魚精蛋(dan)(dan)白副凝(ning)(ning)(ning)試(shi)驗(yan)(yan)（3P試(shi)驗(yan)(yan)）在(zai)(zai)(zai)(zai)(zai)給(gei)(gei)(gei)藥(yao)(yao)前(qian)(qian)后(hou)(hou)(hou)均為(wei)(wei)陰性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)，表明(ming)(ming)(ming)(ming)(ming)(ming)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)不(bu)(bu)引(yin)起血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)中(zhong)纖(xian)維(wei)蛋(dan)(dan)白降(jiang)(jiang)解產物(wu)（FDP）增(zeng)加(jia)(jia)(jia)(jia)(jia)，不(bu)(bu)會(hui)(hui)造成(cheng)(cheng)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)液(ye)高(gao)凝(ning)(ning)(ning)狀態。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)200mg/kg加(jia)(jia)(jia)(jia)(jia)肝(gan)素(su)(su)(su)(su)(su)62.5u/kg，靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，與(yu)(yu)(yu)(yu)(yu)鹽(yan)水(shui)組(zu)(zu)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)時(shi)間(jian)(jian)無(wu)(wu)(wu)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)差異(yi)，表明(ming)(ming)(ming)(ming)(ming)(ming)有(you)(you)(you)(you)(you)(you)(you)抗(kang)(kang)(kang)肝(gan)素(su)(su)(su)(su)(su)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。按魚精蛋(dan)(dan)白生(sheng)物(wu)檢(jian)定(ding)(ding)(ding)(ding)法(fa)試(shi)驗(yan)(yan)，家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)漿體(ti)(ti)(ti)外(wai)試(shi)驗(yan)(yan)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)1mg不(bu)(bu)能(neng)(neng)(neng)(neng)(neng)(neng)中(zhong)和(he)(he)(he)(he)(he)(he)0.5u肝(gan)素(su)(su)(su)(su)(su)，表明(ming)(ming)(ming)(ming)(ming)(ming)體(ti)(ti)(ti)外(wai)無(wu)(wu)(wu)抗(kang)(kang)(kang)肝(gan)素(su)(su)(su)(su)(su)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。上(shang)(shang)(shang)述實驗(yan)(yan)表明(ming)(ming)(ming)(ming)(ming)(ming)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)與(yu)(yu)(yu)(yu)(yu)其(qi)(qi)(qi)促(cu)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)和(he)(he)(he)(he)(he)(he)抗(kang)(kang)(kang)纖(xian)溶(rong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)雙重(zhong)(zhong)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)相(xiang)(xiang)(xiang)(xiang)關(guan)(guan)(guan)(guan)。其(qi)(qi)(qi)縮(suo)(suo)短(duan)(duan)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)酶(mei)原(yuan)時(shi)間(jian)(jian)能(neng)(neng)(neng)(neng)(neng)(neng)被(bei)正(zheng)(zheng)常(chang)(chang)(chang)家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)紅素(su)(su)(su)(su)(su)糾正(zheng)(zheng)到正(zheng)(zheng)常(chang)(chang)(chang)水(shui)平，表明(ming)(ming)(ming)(ming)(ming)(ming)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)激(ji)(ji)(ji)(ji)活(huo)(huo)(huo)內(nei)(nei)源性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)系(xi)統，作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)過(guo)(guo)程的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)第一階段。此外(wai)，豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)水(shui)煎(jian)利尚能(neng)(neng)(neng)(neng)(neng)(neng)增(zeng)加(jia)(jia)(jia)(jia)(jia)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)小(xiao)(xiao)(xiao)(xiao)(xiao)板(ban)數(shu)(shu)量(liang)，豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)堿(jian)(jian)提取物(wu)具有(you)(you)(you)(you)(you)(you)(you)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)促(cu)進家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)富(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)小(xiao)(xiao)(xiao)(xiao)(xiao)板(ban)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)漿血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)小(xiao)(xiao)(xiao)(xiao)(xiao)板(ban)聚集作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，也(ye)(ye)與(yu)(yu)(yu)(yu)(yu)豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)相(xiang)(xiang)(xiang)(xiang)關(guan)(guan)(guan)(guan)。豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)有(you)(you)(you)(you)(you)(you)(you)效(xiao)成(cheng)(cheng)分(fen)(fen)(fen)(fen)可(ke)(ke)(ke)(ke)能(neng)(neng)(neng)(neng)(neng)(neng)是(shi)(shi)具有(you)(you)(you)(you)(you)(you)(you)一定(ding)(ding)(ding)(ding)結(jie)(jie)(jie)構(gou)特(te)點的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)纖(xian)維(wei)蛋(dan)(dan)由體(ti)(ti)(ti)問。經(jing)柱色(se)(se)譜(pu)分(fen)(fen)(fen)(fen)離(li)(li)(li)(li)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)得3個(ge)組(zu)(zu)分(fen)(fen)(fen)(fen)（Fl相(xiang)(xiang)(xiang)(xiang)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)分(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)質(zhi)(zhi)(zhi)量(liang)3萬以上(shang)(shang)(shang)，F2相(xiang)(xiang)(xiang)(xiang)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)分(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)質(zhi)(zhi)(zhi)量(liang) 1萬以下(xia)(xia)和(he)(he)(he)(he)(he)(he)F3相(xiang)(xiang)(xiang)(xiang)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)分(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)質(zhi)(zhi)(zhi)量(liang)6000以下(xia)(xia)），各組(zu)(zu)分(fen)(fen)(fen)(fen)200mg/kg分(fen)(fen)(fen)(fen)別(bie)給(gei)(gei)(gei)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)球(qiu)后(hou)(hou)(hou)靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，結(jie)(jie)(jie)果(guo)3個(ge)組(zu)(zu)分(fen)(fen)(fen)(fen)均有(you)(you)(you)(you)(you)(you)(you)縮(suo)(suo)短(duan)(duan)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)時(shi)間(jian)(jian)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，其(qi)(qi)(qi)中(zhong)F2促(cu)凝(ning)(ning)(ning)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)較(jiao)強。另有(you)(you)(you)(you)(you)(you)(you)報(bao)道(dao)認(ren)為(wei)(wei)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)有(you)(you)(you)(you)(you)(you)(you)效(xiao)成(cheng)(cheng)分(fen)(fen)(fen)(fen)為(wei)(wei)多(duo)(duo)肽，多(duo)(duo)數(shu)(shu)抗(kang)(kang)(kang)纖(xian)溶(rong)藥(yao)(yao)物(wu)結(jie)(jie)(jie)構(gou)骨(gu)架類似賴氨(an)酸(suan)，多(duo)(duo)肽分(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)中(zhong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)氨(an)基酸(suan)（賴氨(an)酸(suan)）和(he)(he)(he)(he)(he)(he)羧(suo)基可(ke)(ke)(ke)(ke)能(neng)(neng)(neng)(neng)(neng)(neng)是(shi)(shi)抗(kang)(kang)(kang)纖(xian)溶(rong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)化(hua)(hua)學結(jie)(jie)(jie)構(gou)。除止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)外(wai)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)160mg/kg，靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)全(quan)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)粘度(du)(du)(du)和(he)(he)(he)(he)(he)(he)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)漿粘度(du)(du)(du)及(ji)(ji)紅細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)比(bi)穿在(zai)(zai)(zai)(zai)(zai)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)藥(yao)(yao)前(qian)(qian)后(hou)(hou)(hou)無(wu)(wu)(wu)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)差異(yi)。豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)液(ye)0.2g/kg，靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，藥(yao)(yao)后(hou)(hou)(hou)1h，家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)白細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)總數(shu)(shu)由10960/mm3減(jian)(jian)(jian)至(zhi)3500/mm3，3-5h后(hou)(hou)(hou)逐(zhu)漸(jian)(jian)并(bing)持續(xu)上(shang)(shang)(shang)升(sheng)，至(zhi)24h后(hou)(hou)(hou)，白細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)總數(shu)(shu)達(da)藥(yao)(yao)前(qian)(qian)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)1-5倍(bei)(bei)(bei)。白細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)分(fen)(fen)(fen)(fen)類在(zai)(zai)(zai)(zai)(zai)要(yao)表現(xian)為(wei)(wei)中(zhong)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)粒細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)增(zeng)加(jia)(jia)(jia)(jia)(jia)和(he)(he)(he)(he)(he)(he)淋(lin)巴細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)減(jian)(jian)(jian)少(shao)(shao)。豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)制(zhi)(zhi)(zhi)劑(ji)(ji)（H）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)流(liu)基封閉(bi)(bi)劑(ji)(ji)（如(ru)(ru)(ru)氯化(hua)(hua)汞和(he)(he)(he)(he)(he)(he)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)氯汞苯甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)酸(suan)）所(suo)致(zhi)(zhi)(zhi)人(ren)和(he)(he)(he)(he)(he)(he)免(mian)紅細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)溶(rong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)有(you)(you)(you)(you)(you)(you)(you)一定(ding)(ding)(ding)(ding)保(bao)(bao)(bao)護(hu)(hu)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，但(dan)(dan)(dan)不(bu)(bu)能(neng)(neng)(neng)(neng)(neng)(neng)完(wan)(wan)全(quan)消除其(qi)(qi)(qi)溶(rong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)；H也(ye)(ye)能(neng)(neng)(neng)(neng)(neng)(neng)使(shi)(shi)(shi)冷藏(zang)(zang)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)液(ye)中(zhong)紅細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)溶(rong)解量(liang)減(jian)(jian)(jian)少(shao)(shao)，紅細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)內(nei)(nei)乳酸(suan)脫氫酶(mei)（LDH）失(shi)活(huo)(huo)(huo)減(jian)(jian)(jian)慢(man)，而(er)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)紅細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)有(you)(you)(you)(you)(you)(you)(you)保(bao)(bao)(bao)護(hu)(hu)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。2．對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)未(wei)受孕(yun)(yun)(yun)動(dong)情(qing)期小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)離(li)(li)(li)(li)體(ti)(ti)(ti)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)有(you)(you)(you)(you)(you)(you)(you)興(xing)奮(fen)(fen)(fen)(fen)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，使(shi)(shi)(shi)收縮(suo)(suo)頻率(lv)(lv)和(he)(he)(he)(he)(he)(he)幅(fu)度(du)(du)(du)均顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)增(zeng)加(jia)(jia)(jia)(jia)(jia)，但(dan)(dan)(dan)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)非動(dong)情(qing)期者無(wu)(wu)(wu)效(xiao)，提示(shi)其(qi)(qi)(qi)興(xing)奮(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)與(yu)(yu)(yu)(yu)(yu)雌(ci)(ci)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)激(ji)(ji)(ji)(ji)素(su)(su)(su)(su)(su)水(shui)平相(xiang)(xiang)(xiang)(xiang)關(guan)(guan)(guan)(guan)。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)0.8mg/ml，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)皮(pi)(pi)下(xia)(xia)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)己烯雌(ci)(ci)酚(fen)后(hou)(hou)(hou)摘(zhai)(zhai)除的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)未(wei)孕(yun)(yun)(yun)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)有(you)(you)(you)(you)(you)(you)(you)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)興(xing)奮(fen)(fen)(fen)(fen)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，使(shi)(shi)(shi)收縮(suo)(suo)幅(fu)度(du)(du)(du)和(he)(he)(he)(he)(he)(he)頻率(lv)(lv)分(fen)(fen)(fen)(fen)別(bie)增(zeng)加(jia)(jia)(jia)(jia)(jia)31%和(he)(he)(he)(he)(he)(he)86%，收縮(suo)(suo)呈(cheng)節律性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)，濃(nong)度(du)(du)(du)提高(gao)20倍(bei)(bei)(bei)也(ye)(ye)未(wei)見(jian)強直性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)收縮(suo)(suo)。3.1mg/ml對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)大(da)鼠(shu)(shu)離(li)(li)(li)(li)體(ti)(ti)(ti)于(yu)(yu)它也(ye)(ye)有(you)(you)(you)(you)(you)(you)(you)類似的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)興(xing)奮(fen)(fen)(fen)(fen)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。未(wei)孕(yun)(yun)(yun)大(da)鼠(shu)(shu)在(zai)(zai)(zai)(zai)(zai)皮(pi)(pi)下(xia)(xia)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)雌(ci)(ci)二醇36h后(hou)(hou)(hou)，按Magnus法(fa)制(zhi)(zhi)(zhi)備的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)本，在(zai)(zai)(zai)(zai)(zai)低(di)鈣(gai)(gai)情(qing)況下(xia)(xia)，滴加(jia)(jia)(jia)(jia)(jia)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)于(yu)(yu)出現(xian)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)節律性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)收縮(suo)(suo)，追加(jia)(jia)(jia)(jia)(jia)20倍(bei)(bei)(bei)量(liang)也(ye)(ye)不(bu)(bu)產生(sheng)強直性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)收縮(suo)(suo)。另有(you)(you)(you)(you)(you)(you)(you)試(shi)驗(yan)(yan)排除了婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)興(xing)奮(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)與(yu)(yu)(yu)(yu)(yu)其(qi)(qi)(qi)含(han)鈣(gai)(gai)相(xiang)(xiang)(xiang)(xiang)關(guan)(guan)(guan)(guan)。如(ru)(ru)(ru)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)了興(xing)奮(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)效(xiao)價，在(zai)(zai)(zai)(zai)(zai)大(da)鼠(shu)(shu)離(li)(li)(li)(li)體(ti)(ti)(ti)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)1mg婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)相(xiang)(xiang)(xiang)(xiang)當5.0×10-5u垂體(ti)(ti)(ti)后(hou)(hou)(hou)葉(xie)素(su)(su)(su)(su)(su)，在(zai)(zai)(zai)(zai)(zai)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)相(xiang)(xiang)(xiang)(xiang)當1.8×10(6)u；垂體(ti)(ti)(ti)后(hou)(hou)(hou)葉(xie)素(su)(su)(su)(su)(su)。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)20mg和(he)(he)(he)(he)(he)(he)200mg/kg靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)個(ge)位家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)也(ye)(ye)有(you)(you)(you)(you)(you)(you)(you)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)興(xing)奮(fen)(fen)(fen)(fen)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，使(shi)(shi)(shi)收縮(suo)(suo)幅(fu)度(du)(du)(du)與(yu)(yu)(yu)(yu)(yu)頻率(lv)(lv)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)增(zeng)加(jia)(jia)(jia)(jia)(jia)。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)能(neng)(neng)(neng)(neng)(neng)(neng)使(shi)(shi)(shi)于(yu)(yu)它重(zhong)(zhong)量(liang)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)著(zhu)(zhu)(zhu)減(jian)(jian)(jian)輕，組(zu)(zu)織切片(pian)檢(jian)查，子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)內(nei)(nei)膜(mo)(mo)(mo)上(shang)(shang)(shang)皮(pi)(pi)細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)排列整齊，子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)腺(xian)體(ti)(ti)(ti)租短(duan)(duan)，粘膜(mo)(mo)(mo)組(zu)(zu)織細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)活(huo)(huo)(huo)躍(yue)，毛(mao)(mao)細(xi)(xi)(xi)(xi)(xi)(xi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)管(guan)和(he)(he)(he)(he)(he)(he)個(ge)靜(jing)(jing)脈(mo)(mo)充血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)，有(you)(you)(you)(you)(you)(you)(you)利于(yu)(yu)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)內(nei)(nei)膜(mo)(mo)(mo)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)修(xiu)復。對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)摘(zhai)(zhai)除卵(luan)(luan)巢(chao)(chao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)服(fu)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)后(hou)(hou)(hou)，子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)有(you)(you)(you)(you)(you)(you)(you)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)增(zeng)重(zhong)(zhong)現(xian)象。在(zai)(zai)(zai)(zai)(zai)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)3個(ge)組(zu)(zu)分(fen)(fen)(fen)(fen)中(zhong)，F3興(xing)奮(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)較(jiao)強，相(xiang)(xiang)(xiang)(xiang)當于(yu)(yu)原(yuan)粉的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)6.1倍(bei)(bei)(bei)，使(shi)(shi)(shi)大(da)鼠(shu)(shu)離(li)(li)(li)(li)體(ti)(ti)(ti)于(yu)(yu)官向(xiang)發性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)收縮(suo)(suo)幅(fu)度(du)(du)(du)加(jia)(jia)(jia)(jia)(jia)大(da)，收縮(suo)(suo)基線升(sheng)高(gao)；而(er)F2使(shi)(shi)(shi)自發性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)收縮(suo)(suo)曲線的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)基線降(jiang)(jiang)低(di)，表現(xian)出抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)效(xiao)應。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)500mg/（kg·d）腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，連(lian)(lian)續(xu)2d，小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)陰道(dao)角(jiao)化(hua)(hua)細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)試(shi)驗(yan)(yan)法(fa)，試(shi)驗(yan)(yan)表明(ming)(ming)(ming)(ming)(ming)(ming)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)于(yu)(yu)有(you)(you)(you)(you)(you)(you)(you)一定(ding)(ding)(ding)(ding)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)促(cu)陰道(dao)上(shang)(shang)(shang)皮(pi)(pi)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)化(hua)(hua)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，但(dan)(dan)(dan)無(wu)(wu)(wu)促(cu)進子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)內(nei)(nei)股增(zeng)生(sheng)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，也(ye)(ye)無(wu)(wu)(wu)促(cu)卵(luan)(luan)巢(chao)(chao)分(fen)(fen)(fen)(fen)泌(mi)(mi)雌(ci)(ci)激(ji)(ji)(ji)(ji)素(su)(su)(su)(su)(su)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，但(dan)(dan)(dan)能(neng)(neng)(neng)(neng)(neng)(neng)部分(fen)(fen)(fen)(fen)括抗(kang)(kang)(kang)絨毛(mao)(mao)膜(mo)(mo)(mo)促(cu)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)腺(xian)素(su)(su)(su)(su)(su)（HCG）的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)促(cu)卵(luan)(luan)巢(chao)(chao)分(fen)(fen)(fen)(fen)泌(mi)(mi)雌(ci)(ci)激(ji)(ji)(ji)(ji)素(su)(su)(su)(su)(su)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。功(gong)(gong)能(neng)(neng)(neng)(neng)(neng)(neng)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)出血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)（功(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)）的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)主(zhu)(zhu)要(yao)病因(yin)系(xi)下(xia)(xia)丘腦-垂體(ti)(ti)(ti)-卵(luan)(luan)巢(chao)(chao)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)分(fen)(fen)(fen)(fen)泌(mi)(mi)軸(zhou)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)功(gong)(gong)能(neng)(neng)(neng)(neng)(neng)(neng)紊亂，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)治療功(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)，除通(tong)(tong)過(guo)(guo)促(cu)凝(ning)(ning)(ning)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)與(yu)(yu)(yu)(yu)(yu)抗(kang)(kang)(kang)纖(xian)溶(rong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)雙重(zhong)(zhong)止(zhi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，促(cu)進血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)小(xiao)(xiao)(xiao)(xiao)(xiao)板(ban)聚集作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)內(nei)(nei)膜(mo)(mo)(mo)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)管(guan)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)調節作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，節律性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)收縮(suo)(suo)于(yu)(yu)官平滑(hua)肌(ji)等作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)外(wai)，也(ye)(ye)可(ke)(ke)(ke)(ke)能(neng)(neng)(neng)(neng)(neng)(neng)與(yu)(yu)(yu)(yu)(yu)其(qi)(qi)(qi)調節下(xia)(xia)丘腦一垂體(ti)(ti)(ti)一卵(luan)(luan)巢(chao)(chao)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)內(nei)(nei)分(fen)(fen)(fen)(fen)泌(mi)(mi)軸(zhou)功(gong)(gong)能(neng)(neng)(neng)(neng)(neng)(neng)相(xiang)(xiang)(xiang)(xiang)關(guan)(guan)(guan)(guan)。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)通(tong)(tong)過(guo)(guo)上(shang)(shang)(shang)述作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，使(shi)(shi)(shi)更年期功(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)患者閉(bi)(bi)經(jing)，其(qi)(qi)(qi)他年齡(ling)期功(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)者，月經(jing)周期規(gui)律，從而(er)發揮其(qi)(qi)(qi)治療功(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。3．對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)平滑(hua)肌(ji)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)除上(shang)(shang)(shang)述對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)平滑(hua)肌(ji)有(you)(you)(you)(you)(you)(you)(you)興(xing)奮(fen)(fen)(fen)(fen)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)外(wai)，豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)煎(jian)劑(ji)(ji)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)兔(tu)(tu)(tu)(tu)(tu)離(li)(li)(li)(li)體(ti)(ti)(ti)腸(chang)管(guan)有(you)(you)(you)(you)(you)(you)(you)興(xing)奮(fen)(fen)(fen)(fen)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，使(shi)(shi)(shi)其(qi)(qi)(qi)運(yun)動(dong)加(jia)(jia)(jia)(jia)(jia)強，張(zhang)力升(sheng)高(gao)。另有(you)(you)(you)(you)(you)(you)(you)報(bao)道(dao)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)2mg/ml濃(nong)度(du)(du)(du)時(shi)，能(neng)(neng)(neng)(neng)(neng)(neng)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)降(jiang)(jiang)低(di)兔(tu)(tu)(tu)(tu)(tu)離(li)(li)(li)(li)體(ti)(ti)(ti)回腸(chang)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)蠕動(dong)，使(shi)(shi)(shi)蠕動(dong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)幅(fu)度(du)(du)(du)降(jiang)(jiang)低(di)和(he)(he)(he)(he)(he)(he)頻率(lv)(lv)減(jian)(jian)(jian)慢(man)，但(dan)(dan)(dan)不(bu)(bu)能(neng)(neng)(neng)(neng)(neng)(neng)完(wan)(wan)全(quan)桔抗(kang)(kang)(kang)1.7×102mg/ml氨(an)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)酸(suan)膽(dan)堿(jian)(jian)所(suo)致(zhi)(zhi)(zhi)腸(chang)管(guan)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)收縮(suo)(suo)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)2mg/ml未(wei)能(neng)(neng)(neng)(neng)(neng)(neng)引(yin)起豚鼠(shu)(shu)氣管(guan)條收縮(suo)(suo)，但(dan)(dan)(dan)能(neng)(neng)(neng)(neng)(neng)(neng)使(shi)(shi)(shi)10-3mol/L。組(zu)(zu)胺所(suo)致(zhi)(zhi)(zhi)收縮(suo)(suo)幅(fu)度(du)(du)(du)減(jian)(jian)(jian)弱(ruo)28%。4．對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)心(xin)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)管(guan)系(xi)統的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)煎(jian)劑(ji)(ji)和(he)(he)(he)(he)(he)(he)混懸劑(ji)(ji)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)正(zheng)(zheng)常(chang)(chang)(chang)和(he)(he)(he)(he)(he)(he)缺鈣(gai)(gai)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)蟾(chan)(chan)蜍(chu)(chu)離(li)(li)(li)(li)體(ti)(ti)(ti)心(xin)臟(zang)均有(you)(you)(you)(you)(you)(you)(you)強心(xin)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，缺鈣(gai)(gai)時(shi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)更明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)，并(bing)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)毛(mao)(mao)果(guo)會(hui)(hui)香堿(jian)(jian)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)心(xin)臟(zang)抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)有(you)(you)(you)(you)(you)(you)(you)一定(ding)(ding)(ding)(ding)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)恢復作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)2mg/ml使(shi)(shi)(shi)蟾(chan)(chan)蜍(chu)(chu)離(li)(li)(li)(li)體(ti)(ti)(ti)心(xin)臟(zang)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)收縮(suo)(suo)幅(fu)度(du)(du)(du)增(zeng)加(jia)(jia)(jia)(jia)(jia)，在(zai)(zai)(zai)(zai)(zai)濃(nong)度(du)(du)(du)為(wei)(wei)4mg/ml時(shi)，心(xin)縮(suo)(suo)幅(fu)度(du)(du)(du)先輕度(du)(du)(du)減(jian)(jian)(jian)少(shao)(shao)，后(hou)(hou)(hou)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)增(zeng)加(jia)(jia)(jia)(jia)(jia)。豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)液(ye)0.2g/kg靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)使(shi)(shi)(shi)麻醉(zui)貓血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)壓光(guang)升(sheng)后(hou)(hou)(hou)降(jiang)(jiang)，心(xin)率(lv)(lv)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)增(zeng)加(jia)(jia)(jia)(jia)(jia)，心(xin)電(dian)圖未(wei)見(jian)異(yi)常(chang)(chang)(chang)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)于(yu)(yu)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)壓和(he)(he)(he)(he)(he)(he)心(xin)率(lv)(lv)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，不(bu)(bu)受領(ling)先腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)利血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)平的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)影(ying)響，表明(ming)(ming)(ming)(ming)(ming)(ming)與(yu)(yu)(yu)(yu)(yu)交感(gan)(gan)神經(jing)無(wu)(wu)(wu)關(guan)(guan)(guan)(guan)。另有(you)(you)(you)(you)(you)(you)(you)報(bao)道(dao)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)160mg/kg靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，藥(yao)(yao)后(hou)(hou)(hou)30min使(shi)(shi)(shi)麻醉(zui)兔(tu)(tu)(tu)(tu)(tu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)壓從藥(yao)(yao)前(qian)(qian)13.3kPa先降(jiang)(jiang)至(zhi)7.9kPa繼而(er)輕度(du)(du)(du)升(sheng)至(zhi)14.1kPa。隨血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)壓變(bian)(bian)化(hua)(hua)球(qiu)結(jie)(jie)(jie)膜(mo)(mo)(mo)微循環的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)流(liu)速度(du)(du)(du)、流(liu)態和(he)(he)(he)(he)(he)(he)A/V直徑(jing)也(ye)(ye)產生(sheng)相(xiang)(xiang)(xiang)(xiang)應的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)雙相(xiang)(xiang)(xiang)(xiang)變(bian)(bian)化(hua)(hua)。宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)0.6g/kg，灌胃(wei)，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)麻醉(zui)兔(tu)(tu)(tu)(tu)(tu)呼(hu)吸(xi)(xi)和(he)(he)(he)(he)(he)(he)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)壓無(wu)(wu)(wu)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)影(ying)響，在(zai)(zai)(zai)(zai)(zai)長(chang)毒實驗(yan)(yan)中(zhong)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)大(da)心(xin)率(lv)(lv)和(he)(he)(he)(he)(he)(he)心(xin)電(dian)圖無(wu)(wu)(wu)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)影(ying)響。5．抗(kang)(kang)(kang)炎(yan)(yan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)經(jing)實驗(yan)(yan)表明(ming)(ming)(ming)(ming)(ming)(ming)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)組(zu)(zu)胺、醋酸(suan)和(he)(he)(he)(he)(he)(he)蛋(dan)(dan)清(qing)誘(you)發的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)急性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)滲出性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)炎(yan)(yan)癥(zheng)及(ji)(ji)棉球(qiu)刺激(ji)(ji)(ji)(ji)所(suo)致(zhi)(zhi)(zhi)慢(man)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)增(zeng)生(sheng)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)炎(yan)(yan)癥(zheng)，均名抗(kang)(kang)(kang)炎(yan)(yan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de) 3個(ge)組(zu)(zu)分(fen)(fen)(fen)(fen)F1、F2和(he)(he)(he)(he)(he)(he)F3各200mg/kg，分(fen)(fen)(fen)(fen)別(bie)腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，結(jie)(jie)(jie)果(guo)F2和(he)(he)(he)(he)(he)(he)民對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)大(da)鼠(shu)(shu)蛋(dan)(dan)清(qing)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)足(zu)腫(zhong)有(you)(you)(you)(you)(you)(you)(you)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，而(er)F1無(wu)(wu)(wu)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)抗(kang)(kang)(kang)炎(yan)(yan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)500mg/kg腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，使(shi)(shi)(shi)腎(shen)(shen)上(shang)(shang)(shang)腺(xian)中(zhong)維(wei)中(zhong)素(su)(su)(su)(su)(su)C含(han)量(liang)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)降(jiang)(jiang)低(di)，并(bing)且對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)去腎(shen)(shen)上(shang)(shang)(shang)腺(xian)大(da)鼠(shu)(shu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)蛋(dan)(dan)清(qing)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)足(zu)腫(zhong)無(wu)(wu)(wu)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。上(shang)(shang)(shang)述實驗(yan)(yan)表明(ming)(ming)(ming)(ming)(ming)(ming)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)于(yu)(yu)中(zhong)分(fen)(fen)(fen)(fen)子(zi)(zi)(zi)(zi)量(liang)較(jiao)小(xiao)(xiao)(xiao)(xiao)(xiao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)多(duo)(duo)肽有(you)(you)(you)(you)(you)(you)(you)抗(kang)(kang)(kang)炎(yan)(yan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)于(yu)(yu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)抗(kang)(kang)(kang)炎(yan)(yan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)與(yu)(yu)(yu)(yu)(yu)腎(shen)(shen)上(shang)(shang)(shang)腺(xian)皮(pi)(pi)質(zhi)(zhi)(zhi)相(xiang)(xiang)(xiang)(xiang)關(guan)(guan)(guan)(guan)，呈(cheng)促(cu)腎(shen)(shen)上(shang)(shang)(shang)腺(xian)皮(pi)(pi)質(zhi)(zhi)(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。此外(wai)，豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)散(san)(san)能(neng)(neng)(neng)(neng)(neng)(neng)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)抗(kang)(kang)(kang)組(zu)(zu)胺所(suo)致(zhi)(zhi)(zhi)大(da)鼠(shu)(shu)毛(mao)(mao)細(xi)(xi)(xi)(xi)(xi)(xi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)管(guan)通(tong)(tong)透性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)增(zeng)加(jia)(jia)(jia)(jia)(jia)及(ji)(ji)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)實驗(yan)(yan)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)腹(fu)(fu)膜(mo)(mo)(mo)炎(yan)(yan)。6．抗(kang)(kang)(kang)感(gan)(gan)染作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)煎(jian)劑(ji)(ji)在(zai)(zai)(zai)(zai)(zai)體(ti)(ti)(ti)外(wai)不(bu)(bu)能(neng)(neng)(neng)(neng)(neng)(neng)抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)金葡菌(jun)(jun)生(sheng)長(chang)，在(zai)(zai)(zai)(zai)(zai)腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)金葡菌(jun)(jun)或(huo)(huo)溶(rong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)鏈球(qiu)菌(jun)(jun)后(hou)(hou)(hou)，灌胃(wei)給(gei)(gei)(gei)予豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)煎(jian)劑(ji)(ji)或(huo)(huo)混懸液(ye)，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)無(wu)(wu)(wu)保(bao)(bao)(bao)護(hu)(hu)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，不(bu)(bu)能(neng)(neng)(neng)(neng)(neng)(neng)防(fang)止(zhi)其(qi)(qi)(qi)死亡。如(ru)(ru)(ru)先給(gei)(gei)(gei)家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)氨(an)肽素(su)(su)(su)(su)(su)（豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)提取物(wu)）2ml，每日(ri)(ri)(ri)(ri)1次，連(lian)(lian)續(xu)6d再靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)金黃色(se)(se)葡萄(tao)球(qiu)菌(jun)(jun)活(huo)(huo)(huo)菌(jun)(jun)液(ye)1ml（含(han)20億(yi)個(ge)）則有(you)(you)(you)(you)(you)(you)(you)抗(kang)(kang)(kang)感(gan)(gan)染作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，可(ke)(ke)(ke)(ke)防(fang)止(zhi)家(jia)(jia)兔(tu)(tu)(tu)(tu)(tu)死亡；但(dan)(dan)(dan)如(ru)(ru)(ru)先靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)金葡菌(jun)(jun)，再用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)氨(an)肽素(su)(su)(su)(su)(su)，則對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)動(dong)物(wu)無(wu)(wu)(wu)保(bao)(bao)(bao)護(hu)(hu)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。氨(an)肽素(su)(su)(su)(su)(su)0.1ml，腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，每日(ri)(ri)(ri)(ri)1次，連(lian)(lian)續(xu)5d小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)清(qing)溶(rong)菌(jun)(jun)酶(mei)第4日(ri)(ri)(ri)(ri)開(kai)始(shi)上(shang)(shang)(shang)升(sheng)，第9日(ri)(ri)(ri)(ri)達(da)高(gao)峰，氨(an)肽素(su)(su)(su)(su)(su)使(shi)(shi)(shi)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)清(qing)溶(rong)菌(jun)(jun)酶(mei)含(han)量(liang)增(zeng)加(jia)(jia)(jia)(jia)(jia)，可(ke)(ke)(ke)(ke)能(neng)(neng)(neng)(neng)(neng)(neng)與(yu)(yu)(yu)(yu)(yu)抗(kang)(kang)(kang)感(gan)(gan)染有(you)(you)(you)(you)(you)(you)(you)關(guan)(guan)(guan)(guan)。7．其(qi)(qi)(qi)他作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)制(zhi)(zhi)(zhi)劑(ji)(ji)（H）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)人(ren)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)乳酸(suan)脫氫酶(mei)（LDH,一種(zhong)流(liu)基酶(mei)）無(wu)(wu)(wu)直接作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，但(dan)(dan)(dan)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)流(liu)基酶(mei)抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)劑(ji)(ji)澳醋酸(suan)（BA）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)LDH的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)有(you)(you)(you)(you)(you)(you)(you)解除抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，如(ru)(ru)(ru)先加(jia)(jia)(jia)(jia)(jia) H，后(hou)(hou)(hou)加(jia)(jia)(jia)(jia)(jia) BA則保(bao)(bao)(bao)護(hu)(hu)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)更明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)。但(dan)(dan)(dan) H不(bu)(bu)能(neng)(neng)(neng)(neng)(neng)(neng)完(wan)(wan)全(quan)清(qing)除 BA對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)流(liu)基酶(mei)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)，而(er)只減(jian)(jian)(jian)輕抑(yi)(yi)(yi)(yi)制(zhi)(zhi)(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。在(zai)(zai)(zai)(zai)(zai)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)飼(si)料中(zhong)每日(ri)(ri)(ri)(ri)每只加(jia)(jia)(jia)(jia)(jia)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)粉劑(ji)(ji)1.84mg，在(zai)(zai)(zai)(zai)(zai)38日(ri)(ri)(ri)(ri)后(hou)(hou)(hou)，除小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)重(zhong)(zhong)量(liang)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)降(jiang)(jiang)低(di)外(wai)（上(shang)(shang)(shang)述），腎(shen)(shen)上(shang)(shang)(shang)腺(xian)重(zhong)(zhong)量(liang)也(ye)(ye)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)降(jiang)(jiang)低(di)，而(er)體(ti)(ti)(ti)重(zhong)(zhong)增(zeng)加(jia)(jia)(jia)(jia)(jia)。腎(shen)(shen)上(shang)(shang)(shang)腺(xian)皮(pi)(pi)質(zhi)(zhi)(zhi)束狀帶和(he)(he)(he)(he)(he)(he)網狀帶較(jiao)活(huo)(huo)(huo)躍(yue)，表明(ming)(ming)(ming)(ming)(ming)(ming)糖皮(pi)(pi)質(zhi)(zhi)(zhi)激(ji)(ji)(ji)(ji)素(su)(su)(su)(su)(su)和(he)(he)(he)(he)(he)(he)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)激(ji)(ji)(ji)(ji)素(su)(su)(su)(su)(su)分(fen)(fen)(fen)(fen)泌(mi)(mi)有(you)(you)(you)(you)(you)(you)(you)所(suo)增(zeng)加(jia)(jia)(jia)(jia)(jia)。胃(wei)粘膜(mo)(mo)(mo)輕度(du)(du)(du)增(zeng)厚，結(jie)(jie)(jie)構(gou)正(zheng)(zheng)常(chang)(chang)(chang)，可(ke)(ke)(ke)(ke)能(neng)(neng)(neng)(neng)(neng)(neng)有(you)(you)(you)(you)(you)(you)(you)一定(ding)(ding)(ding)(ding)保(bao)(bao)(bao)護(hu)(hu)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)0.6g/kg灌胃(wei)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)自主(zhu)(zhu)活(huo)(huo)(huo)動(dong)光(guang)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)影(ying)響。豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)粉組(zu)(zu)織埋藏(zang)(zang)吸(xi)(xi)收試(shi)驗(yan)(yan)表明(ming)(ming)(ming)(ming)(ming)(ming)，在(zai)(zai)(zai)(zai)(zai)肝(gan)、脾和(he)(he)(he)(he)(he)(he)肌(ji)肉組(zu)(zu)織內(nei)(nei)吸(xi)(xi)收良好，組(zu)(zu)織反(fan)應隨時(shi)間(jian)(jian)逐(zhu)漸(jian)(jian)減(jian)(jian)(jian)輕，損傷組(zu)(zu)織最后(hou)(hou)(hou)由纖(xian)維(wei)組(zu)(zu)織增(zeng)中(zhong)填充。8．毒性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)急性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)毒性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)試(shi)驗(yan)(yan)：小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)每田(tian)(tian)(tian)灌胃(wei)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)于(yu)(yu)0.2g（相(xiang)(xiang)(xiang)(xiang)當人(ren)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)每日(ri)(ri)(ri)(ri)2g的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)250倍(bei)(bei)(bei)），連(lian)(lian)續(xu)7d，無(wu)(wu)(wu)異(yi)常(chang)(chang)(chang)或(huo)(huo)死亡發生(sheng)。氨(an)肽素(su)(su)(su)(su)(su)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)灌胃(wei)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)LD50＞15g/kg。長(chang)期毒性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)試(shi)驗(yan)(yan)：大(da)鼠(shu)(shu)每田(tian)(tian)(tian)灌胃(wei)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)600、300和(he)(he)(he)(he)(he)(he)150mg，連(lian)(lian)續(xu)14d，觀察(cha)3個(ge)月，犬口服(fu)925mg/（kg·d）（相(xiang)(xiang)(xiang)(xiang)當人(ren)每日(ri)(ri)(ri)(ri)2g的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)15倍(bei)(bei)(bei)）和(he)(he)(he)(he)(he)(he)61.7mg/（kg·d），連(lian)(lian)續(xu)給(gei)(gei)(gei)藥(yao)(yao) 45d或(huo)(huo)給(gei)(gei)(gei)犬相(xiang)(xiang)(xiang)(xiang)當人(ren) 2g/d 的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)23倍(bei)(bei)(bei)，連(lian)(lian)續(xu)給(gei)(gei)(gei)藥(yao)(yao)45d結(jie)(jie)(jie)果(guo)動(dong)物(wu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)一般(ban)狀態、食欲、大(da)小(xiao)(xiao)(xiao)(xiao)(xiao)便、體(ti)(ti)(ti)重(zhong)(zhong)及(ji)(ji)呼(hu)吸(xi)(xi)、血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)壓、心(xin)律和(he)(he)(he)(he)(he)(he)心(xin)電(dian)圖等均無(wu)(wu)(wu)異(yi)常(chang)(chang)(chang)，血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)常(chang)(chang)(chang)規(gui)、肝(gan)、腎(shen)(shen)功(gong)(gong)能(neng)(neng)(neng)(neng)(neng)(neng)及(ji)(ji)病理組(zu)(zu)織學檢(jian)查（心(xin)、肝(gan)、脾、腎(shen)(shen)、肺(fei)、胃(wei)腸(chang)、睪丸、子(zi)(zi)(zi)(zi)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)、卵(luan)(luan)巢(chao)(chao)、淋(lin)巴結(jie)(jie)(jie)等）均未(wei)見(jian)異(yi)常(chang)(chang)(chang)變(bian)(bian)化(hua)(hua)，表明(ming)(ming)(ming)(ming)(ming)(ming)本藥(yao)(yao)在(zai)(zai)(zai)(zai)(zai)連(lian)(lian)續(xu)給(gei)(gei)(gei)藥(yao)(yao)過(guo)(guo)程中(zhong)和(he)(he)(he)(he)(he)(he)停藥(yao)(yao)觀察(cha)期均無(wu)(wu)(wu)明(ming)(ming)(ming)(ming)(ming)(ming)顯(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)病變(bian)(bian)和(he)(he)(he)(he)(he)(he)蓄積毒性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。氨(an)肽素(su)(su)(su)(su)(su)6g/kg和(he)(he)(he)(he)(he)(he)2g/kg間(jian)(jian)日(ri)(ri)(ri)(ri)給(gei)(gei)(gei)大(da)鼠(shu)(shu)灌胃(wei)連(lian)(lian)續(xu)90d，5.4g/（kg·d）和(he)(he)(he)(he)(he)(he)2.7g/（kg·d）給(gei)(gei)(gei)犬吞服(fu)，連(lian)(lian)續(xu)60d，結(jie)(jie)(jie)果(guo)動(dong)物(wu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)一般(ban)狀態、體(ti)(ti)(ti)重(zhong)(zhong)、血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)常(chang)(chang)(chang)規(gui)、肝(gan)腎(shen)(shen)功(gong)(gong)能(neng)(neng)(neng)(neng)(neng)(neng)及(ji)(ji)主(zhu)(zhu)要(yao)器官的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)肉眼和(he)(he)(he)(he)(he)(he)病理切片(pian)檢(jian)查也(ye)(ye)均未(wei)見(jian)異(yi)常(chang)(chang)(chang)，表明(ming)(ming)(ming)(ming)(ming)(ming)氨(an)肽素(su)(su)(su)(su)(su)無(wu)(wu)(wu)年期毒性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)反(fan)應。致(zhi)(zhi)(zhi)突變(bian)(bian)試(shi)驗(yan)(yan)，氨(an)肽素(su)(su)(su)(su)(su)和(he)(he)(he)(he)(he)(he)宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)于(yu)(yu)，經(jing)Ames試(shi)驗(yan)(yan)，人(ren)體(ti)(ti)(ti)外(wai)周血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)體(ti)(ti)(ti)內(nei)(nei)、外(wai)染色(se)(se)體(ti)(ti)(ti)畸(ji)變(bian)(bian)試(shi)驗(yan)(yan)及(ji)(ji)小(xiao)(xiao)(xiao)(xiao)(xiao)鼠(shu)(shu)骨(gu)髓多(duo)(duo)染紅細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)微核試(shi)驗(yan)(yan)，均未(wei)見(jian)有(you)(you)(you)(you)(you)(you)(you)致(zhi)(zhi)(zhi)突變(bian)(bian)活(huo)(huo)(huo)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)，證(zheng)明(ming)(ming)(ming)(ming)(ming)(ming)豬(zhu)(zhu)(zhu)蹄(ti)(ti)(ti)甲(jia)(jia)(jia)(jia)(jia)(jia)(jia)提取物(wu)（宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)、氨(an)肽素(su)(su)(su)(su)(su)）無(wu)(wu)(wu)潛(qian)在(zai)(zai)(zai)(zai)(zai)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)致(zhi)(zhi)(zhi)癌和(he)(he)(he)(he)(he)(he)致(zhi)(zhi)(zhi)突變(bian)(bian)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)危(wei)險(xian)性(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)(xing)。致(zhi)(zhi)(zhi)畸(ji)試(shi)驗(yan)(yan)，宮(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)(gong)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)10g/kg和(he)(he)(he)(he)(he)(he)0.5g/kg，從大(da)鼠(shu)(shu)妊(ren)娠(shen)第7日(ri)(ri)(ri)(ri)開(kai)始(shi)給(gei)(gei)(gei)藥(yao)(yao)，連(lian)(lian)續(xu)5d第20日(ri)(ri)(ri)(ri)處死孕(yun)(yun)(yun)鼠(shu)(shu)檢(jian)查，結(jie)(jie)(jie)果(guo)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)妊(ren)娠(shen)大(da)鼠(shu)(shu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)著(zhu)(zhu)(zhu)床數(shu)(shu)，活(huo)(huo)(huo)胎率(lv)(lv)，吸(xi)(xi)收胎及(ji)(ji)死胎率(lv)(lv)和(he)(he)(he)(he)(he)(he)股鼠(shu)(shu)發育，服(fu)仔的(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)(de)骨(gu)銘和(he)(he)(he)(he)(he)(he)內(nei)(nei)臟(zang)均未(wei)見(jian)異(yi)常(chang)(chang)(chang)，表明(ming)(ming)(ming)(ming)(ming)(ming)無(wu)(wu)(wu)致(zhi)(zhi)(zhi)畸(ji)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。過(guo)(guo)敏(min)試(shi)驗(yan)(yan)，婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)寧(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)(ning)100mg/kg給(gei)(gei)(gei)豚鼠(shu)(shu)腹(fu)(fu)腔(qiang)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)，分(fen)(fen)(fen)(fen)別(bie)于(yu)(yu)第2、4星期重(zhong)(zhong)復靜(jing)(jing)脈(mo)(mo)注(zhu)(zhu)(zhu)(zhu)射(she)(she)(she)(she)等量(liang)，均未(wei)見(jian)異(yi)常(chang)(chang)(chang)反(fan)應，表明(ming)(ming)(ming)(ming)(ming)(ming)婦(fu)(fu)(fu)(fu)(fu)(fu)(fu)(fu)血(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)(xue)了無(wu)(wu)(wu)致(zhi)(zhi)(zhi)過(guo)(guo)敏(min)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。
炮制 : 《千金(jin)·食治》：酒浸半日，炙焦用(yong)之。
鑒別 : 理比鑒別(bie)薄層色譜取(qu)本品(pin)(pin)(pin)米粉0.1g,加CH2Cl25ml，溫水浴浸漬15min，過濾，濾液(ye)(ye)作(zuo)供(gong)試(shi)品(pin)(pin)(pin)溶(rong)液(ye)(ye)。另取(qu)膽固醇約102g，加5mlCH2Cl2，振(zhen)搖使溶(rong)解，作(zuo)對(dui)照品(pin)(pin)(pin)溶(rong)液(ye)(ye)。吸取(qu)上述溶(rong)液(ye)(ye)各2μl，分別(bie)點于(yu)(yu)同一硅膠G－CMCNa薄層板上，用(yong)CH2CI2-CHCl3（1：1）為展汗劑，展開兩次，揮(hui)干，噴以10%硫酸乙(yi)醇液(ye)(ye)，于(yu)(yu)110℃加熱(re)5min，結果供(gong)試(shi)品(pin)(pin)(pin)色譜在與對(dui)照品(pin)(pin)(pin)相同的位置上呈相同顏色的紫紅色斑點。
歸經 : 胃；大腸經
性味 : 味(wei)咸(xian)；性微寒
功能主治 : 化痰定喘(chuan)；解(jie)毒生肌。主咳嗽喘(chuan)息；腸癰；痔漏；疝(shan)氣偏墜(zhui)；白禿瘡；凍瘡
用法用量 : 內服：燒灰研末，每次3-9g；或(huo)入丸、散(san)劑。外用(yong)：適量，研末調敷(fu)。
復方 : ①治(zhi)(zhi)久咳嗽喘息：豬(zhu)(zhu)(zhu)蹄合(he)子(zi)(zi)四十九枚(黑者(zhe)，永(yong)浸洗凈(jing))，天(tian)南(nan)星一(yi)枚(大(da)(da)者(zhe)銼(cuo))，款冬花(hua)(帶蕊(rui)者(zhe)末)半兩。上三(san)味，用(yong)(yong)瓶子(zi)(zi)一(yi)枚，鋪豬(zhu)(zhu)(zhu)蹄合(he)子(zi)(zi)在(zai)內，上以天(tian)南(nan)星勻蓋之(zhi)，合(he)了(le)，鹽(yan)泥赤石脂(zhi)固濟(ji)火股，白煙出(chu)為度，候冷(leng)取出(chu)，入(ru)款冬花(hua)未并麝(she)香一(yi)分，龍(long)腦少許(xu)，同研(yan)。每服一(yi)錢匕，食(shi)后煎(jian)桑根白皮湯調下(xia)。(《圣(sheng)濟(ji)總(zong)錄(lu)》黑金散)②治(zhi)(zhi)諸痔(zhi)：豬(zhu)(zhu)(zhu)懸(xuan)(xuan)蹄甲(jia)不(bu)拘(ju)多少，燒(shao)(shao)(shao)存性，為未，陳米湯調二錢，空(kong)心服。(《仁(ren)齋直指方》豬(zhu)(zhu)(zhu)甲(jia)散)③治(zhi)(zhi)牡痔(zhi)主鼠乳，肛門(men)癢痛(tong)，觸著有膿血出(chu)不(bu)絕(jue)：豬(zhu)(zhu)(zhu)懸(xuan)(xuan)蹄殼(燒(shao)(shao)(shao)成(cheng)灰(hui)、研(yan))一(yi)兩，水銀(yin)三(san)大(da)(da)豆許(xu)。上二味，先(xian)(xian)取水銀(yin)，用(yong)(yong)蒸(zheng)棗肉二枚，研(yan)勻，次入(ru)蹄殼灰(hui)，拌和為丸(wan)，如雞頭實大(da)(da)。先(xian)(xian)以鹽(yan)湯洗下(xia)部，納(na)一(yi)丸(wan)，夜臥(wo)時再用(yong)(yong)，以瘥為度。(《圣(sheng)濟(ji)總(zong)錄(lu)》豬(zhu)(zhu)(zhu)蹄灰(hui)丸(wan))④治(zhi)(zhi)小(xiao)兒白禿：豬(zhu)(zhu)(zhu)蹄甲(jia)七(qi)個，每個人白礬一(yi)塊，棗兒一(yi)個，燒(shao)(shao)(shao)存往，研(yan)末，入(ru)輕(qing)松、麻(ma)油調搽。(《綱目》)⑤治(zhi)(zhi)凍(dong)爛瘡(chuang)：豬(zhu)(zhu)(zhu)后懸(xuan)(xuan)蹄一(yi)味，燒(shao)(shao)(shao)為灰(hui)，研(yan)細，以豬(zhu)(zhu)(zhu)脂(zhi)和效之(zhi)。(《圣(sheng)濟(ji)總(zong)錄(lu)》豬(zhu)(zhu)(zhu)蹄膏)
各家論述 : 1.《本(ben)(ben)經(jing)》：主(zhu)五(wu)痔，伏(fu)熱在腸，腸癰內蝕。2.《本(ben)(ben)經(jing)逢(feng)原(yuan)》：治目疾外(wai)障。
摘錄 : 《中華(hua)本草(cao)》
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