美(mei)國學者Koren等對(dui)ALLIANCE研究(jiu)進行了亞(ya)組(zu)分析,2242例冠(guan)心(xin)病伴(ban)高脂血(xue)癥(zheng)的患(huan)者隨機(ji)分入強(qiang)化(hua)他(ta)汀治(zhi)(zhi)療組(zu)或(huo)常(chang)規治(zhi)(zhi)療組(zu)。強(qiang)化(hua)他(ta)汀治(zhi)(zhi)療組(zu)低密度脂蛋(dan)白(LDL-C)的目標值是80mg/dl以下或(huo)阿托(tuo)伐他(ta)汀的最(zui)大劑量(liang)達80mg/d。基線時兩組(zu)估(gu)計腎小(xiao)球濾過率(eGFR)相似(si),隨訪4年后,強(qiang)化(hua)治(zhi)(zhi)療組(zu)eGFR增加了5.5%,而常(chang)規治(zhi)(zhi)療組(zu)則無明顯變化(hua),兩組(zu)安全性(xing)和耐受性(xing)無差(cha)異。研究(jiu)提示在冠(guan)心(xin)病伴(ban)高脂血(xue)癥(zheng)的患(huan)者中(zhong),強(qiang)化(hua)降(jiang)脂有助于腎功(gong)能的改善(shan)。
同時,英國學者(zhe)Shepherd等對TNT研究(jiu)的(de)亞(ya)組(zu)(zu)分析也揭示了(le)強化他(ta)汀(ting)(ting)(ting)(阿托伐(fa)他(ta)汀(ting)(ting)(ting)80mg)和(he)普通(tong)劑量他(ta)汀(ting)(ting)(ting)(阿托伐(fa)他(ta)汀(ting)(ting)(ting)10mg)治(zhi)療對冠(guan)心病(bing)(bing)合并慢性(xing)腎臟病(bing)(bing)的(de)影響。共有(you)10001例(li)冠(guan)心病(bing)(bing)患者(zhe)被隨機、雙盲分入強化他(ta)汀(ting)(ting)(ting)組(zu)(zu)或普通(tong)劑量他(ta)汀(ting)(ting)(ting)組(zu)(zu),9656例(li)患者(zhe)完成試驗(yan)。兩(liang)組(zu)(zu)患者(zhe)在基線時eGFR水平沒有(you)明(ming)顯差(cha)別。
平均(jun)隨訪59.5個月后(hou),兩組(zu)eGFR均(jun)有增加(jia),其中強化(hua)他汀組(zu)eGFR增加(jia)了5.2±0.14ml/min·1.73m2,明顯高于普(pu)通劑量(liang)他汀組(zu)(P
第(di)一(yi)：要(yao)(yao)做到(dao)不(bu)(bu)(bu)吃(chi)(chi)(chi)油(you)性(xing)(xing)(xing)大的(de)(de)(de)(de)(de)(de)食物(wu)(wu)(wu)．第(di)二(er)(er)少(shao)吃(chi)(chi)(chi)甜食．第(di)三不(bu)(bu)(bu)要(yao)(yao)吃(chi)(chi)(chi)動物(wu)(wu)(wu)內(nei)臟(zang)(zang)(zang)(zang)(zang)． 如(ru)果不(bu)(bu)(bu)是(shi)(shi)很(hen)(hen)高(gao)(gao)的(de)(de)(de)(de)(de)(de)話，注意(yi)點是(shi)(shi)沒事(shi)(shi)的(de)(de)(de)(de)(de)(de)，多(duo)吃(chi)(chi)(chi)素(su)(su)(su)菜(cai)少(shao)吃(chi)(chi)(chi)葷菜(cai)．但(dan)吃(chi)(chi)(chi)魚沒事(shi)(shi)，可(ke)(ke)(ke)不(bu)(bu)(bu)能(neng)(neng)(neng)吃(chi)(chi)(chi)無玲片(pian)(pian)的(de)(de)(de)(de)(de)(de)魚． 高(gao)(gao)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)的(de)(de)(de)(de)(de)(de)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)治療(liao) 一(yi)、血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)對(dui)(dui)(dui)(dui)人(ren)(ren)(ren)(ren)體(ti)健康有(you)(you)(you)(you)(you)(you)(you)(you)什(shen)么影(ying)響 血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)一(yi)般(ban)指總(zong)膽(dan)固(gu)(gu)醇(chun)(chun)（TC）、低(di)(di)密(mi)度(du)(du)(du)(du)(du)(du)脂(zhi)(zhi)(zhi)(zhi)(zhi)蛋(dan)白(bai)—膽(dan)固(gu)(gu)醇(chun)(chun)（LDL-C）、高(gao)(gao)密(mi)度(du)(du)(du)(du)(du)(du)脂(zhi)(zhi)(zhi)(zhi)(zhi)蛋(dan)白(bai)—膽(dan)固(gu)(gu)醇(chun)(chun)（HDL-C）及(ji)甘油(you)三酯(zhi)(zhi)(zhi)（TG）。TC損(sun)(sun)(sun)傷血(xue)(xue)(xue)管(guan)(guan)(guan)內(nei)皮細胞，促使(shi)動脈硬化(hua)形(xing)成(cheng)(cheng)和(he)(he)發展(zhan)。TC聚積在血(xue)(xue)(xue)管(guan)(guan)(guan)內(nei)膜(mo)，使(shi)內(nei)膜(mo)增(zeng)厚(hou)及(ji)粥(zhou)樣(yang)斑(ban)(ban)塊(kuai)形(xing)成(cheng)(cheng)，使(shi)管(guan)(guan)(guan)腔(qiang)變(bian)窄(zhai)(zhai)，而(er)(er)冠狀(zhuang)動脈狹窄(zhai)(zhai)會(hui)影(ying)響心(xin)(xin)(xin)(xin)臟(zang)(zang)(zang)(zang)(zang)供氧。LDL-C使(shi)內(nei)膜(mo)表面(mian)的(de)(de)(de)(de)(de)(de)粥(zhou)樣(yang)斑(ban)(ban)塊(kuai)變(bian)得松脆(cui)，容(rong)易脫落(luo)。脫落(luo)的(de)(de)(de)(de)(de)(de)碎屑即栓(shuan)(shuan)(shuan)子，小的(de)(de)(de)(de)(de)(de)栓(shuan)(shuan)(shuan)子又(you)不(bu)(bu)(bu)是(shi)(shi)一(yi)次(ci)(ci)(ci)(ci)脫落(luo)的(de)(de)(de)(de)(de)(de)，全(quan)引(yin)起不(bu)(bu)(bu)穩定性(xing)(xing)(xing)心(xin)(xin)(xin)(xin)絞痛(tong)(tong)。大的(de)(de)(de)(de)(de)(de)栓(shuan)(shuan)(shuan)子堵(du)住了較大的(de)(de)(de)(de)(de)(de)冠狀(zhuang)動脈，可(ke)(ke)(ke)引(yin)起心(xin)(xin)(xin)(xin)肌(ji)(ji)(ji)(ji)梗(geng)死(si)(si)。TG能(neng)(neng)(neng)使(shi)LDL-C不(bu)(bu)(bu)進(jin)(jin)入肝(gan)(gan)(gan)臟(zang)(zang)(zang)(zang)(zang)代謝，而(er)(er)直接進(jin)(jin)入導(dao)致動脈硬化(hua)和(he)(he)粥(zhou)樣(yang)斑(ban)(ban)塊(kuai)崩(beng)解的(de)(de)(de)(de)(de)(de)途徑。TG又(you)使(shi)HDL-C進(jin)(jin)入肝(gan)(gan)(gan)臟(zang)(zang)(zang)(zang)(zang)滅活(huo)，結果HDL-C減少(shao)。HDL-C對(dui)(dui)(dui)(dui)以上(shang)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)造成(cheng)(cheng)的(de)(de)(de)(de)(de)(de)血(xue)(xue)(xue)管(guan)(guan)(guan)損(sun)(sun)(sun)害(hai)有(you)(you)(you)(you)(you)(you)(you)(you)保(bao)護(hu)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，所以HDL-C是(shi)(shi)對(dui)(dui)(dui)(dui)人(ren)(ren)(ren)(ren)有(you)(you)(you)(you)(you)(you)(you)(you)益的(de)(de)(de)(de)(de)(de)脂(zhi)(zhi)(zhi)(zhi)(zhi)蛋(dan)白(bai)。 二(er)(er)、哪些人(ren)(ren)(ren)(ren)要(yao)(yao)服(fu)(fu)(fu)(fu)(fu)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)藥(yao)(yao)(yao)(yao)(yao) 專(zhuan)家(jia)認為(wei)(wei)(wei)，有(you)(you)(you)(you)(you)(you)(you)(you)下(xia)(xia)列危險因素(su)(su)(su)中的(de)(de)(de)(de)(de)(de)兩項(xiang)應(ying)采取降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)治療(liao)：男性(xing)(xing)(xing)早(zao)(zao)發冠心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)或(huo)(huo)(huo)(huo)家(jia)族史者(zhe)(zhe)及(ji)吸煙(yan)、高(gao)(gao)血(xue)(xue)(xue)壓、HDL-C降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)、糖尿病(bing)(bing)(bing)、肥胖、腦血(xue)(xue)(xue)管(guan)(guan)(guan)病(bing)(bing)(bing)或(huo)(huo)(huo)(huo)周圍血(xue)(xue)(xue)管(guan)(guan)(guan)病(bing)(bing)(bing)以及(ji)TC和(he)(he)LDL-C增(zeng)高(gao)(gao)者(zhe)(zhe)，應(ying)盡早(zao)(zao)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)，以預防(fang)(fang)冠心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)的(de)(de)(de)(de)(de)(de)發生，對(dui)(dui)(dui)(dui)腦血(xue)(xue)(xue)管(guan)(guan)(guan)病(bing)(bing)(bing)也有(you)(you)(you)(you)(you)(you)(you)(you)預防(fang)(fang)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。 三、血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)到(dao)什(shen)么水平(ping)需服(fu)(fu)(fu)(fu)(fu)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)藥(yao)(yao)(yao)(yao)(yao) 目(mu)(mu)前(qian)認為(wei)(wei)(wei)，無冠心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)史者(zhe)(zhe)，其(qi)TC≥6.2毫(hao)(hao)(hao)摩爾/升(sheng)(sheng)(sheng)(sheng)(sheng)（240毫(hao)(hao)(hao)克(ke)(ke)(ke)/分(fen)升(sheng)(sheng)(sheng)(sheng)(sheng)）或(huo)(huo)(huo)(huo)LDL-C≥4.2毫(hao)(hao)(hao)摩爾/升(sheng)(sheng)(sheng)(sheng)(sheng)（160毫(hao)(hao)(hao)克(ke)(ke)(ke)/分(fen)升(sheng)(sheng)(sheng)(sheng)(sheng)）；已明(ming)(ming)(ming)確診斷為(wei)(wei)(wei)冠心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)者(zhe)(zhe)（心(xin)(xin)(xin)(xin)絞痛(tong)(tong)、心(xin)(xin)(xin)(xin)肌(ji)(ji)(ji)(ji)缺血(xue)(xue)(xue)、心(xin)(xin)(xin)(xin)肌(ji)(ji)(ji)(ji)梗(geng)死(si)(si)者(zhe)(zhe)），其(qi)TC≥4.2毫(hao)(hao)(hao)摩爾/升(sheng)(sheng)(sheng)(sheng)(sheng)（160毫(hao)(hao)(hao)克(ke)(ke)(ke)/分(fen)升(sheng)(sheng)(sheng)(sheng)(sheng)）或(huo)(huo)(huo)(huo)LDL-C≥2.6毫(hao)(hao)(hao)摩爾/升(sheng)(sheng)(sheng)(sheng)(sheng)（100毫(hao)(hao)(hao)克(ke)(ke)(ke)/分(fen)升(sheng)(sheng)(sheng)(sheng)(sheng)），即應(ying)服(fu)(fu)(fu)(fu)(fu)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)藥(yao)(yao)(yao)(yao)(yao)。 四、如(ru)何選用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu) TC值增(zeng)高(gao)(gao)者(zhe)(zhe)，可(ke)(ke)(ke)選用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)下(xia)(xia)列藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)： 首(shou)(shou)烏片(pian)(pian) 內(nei)含卵(luan)磷(lin)脂(zhi)(zhi)(zhi)(zhi)(zhi)及(ji)大黃根(gen)酸(suan)(suan)(suan)，可(ke)(ke)(ke)引(yin)起輕(qing)(qing)(qing)度(du)(du)(du)(du)(du)(du)腹(fu)瀉(xie)，使(shi)膽(dan)固(gu)(gu)醇(chun)(chun)排泄量(liang)增(zeng)加。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)3片(pian)(pian)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)3次(ci)(ci)(ci)(ci)。此(ci)藥(yao)(yao)(yao)(yao)(yao)因易致腹(fu)瀉(xie)，有(you)(you)(you)(you)(you)(you)(you)(you)慢性(xing)(xing)(xing)腹(fu)瀉(xie)者(zhe)(zhe)宜(yi)慎(shen)(shen)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。 脈安(an)沖劑(ji) 由(you)(you)山楂、麥芽組(zu)(zu)成(cheng)(cheng)，有(you)(you)(you)(you)(you)(you)(you)(you)消食化(hua)積功(gong)(gong)能(neng)(neng)(neng)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)1袋(dai)（18克(ke)(ke)(ke)），每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)2次(ci)(ci)(ci)(ci)沖服(fu)(fu)(fu)(fu)(fu)。服(fu)(fu)(fu)(fu)(fu)藥(yao)(yao)(yao)(yao)(yao)后(hou)(hou)偶有(you)(you)(you)(you)(you)(you)(you)(you)泛酸(suan)(suan)(suan)、胃(wei)內(nei)不(bu)(bu)(bu)適(shi)(shi)、輕(qing)(qing)(qing)瀉(xie)等(deng)(deng)副(fu)反應(ying)，胃(wei)酸(suan)(suan)(suan)過多(duo)或(huo)(huo)(huo)(huo)有(you)(you)(you)(you)(you)(you)(you)(you)潰瘍病(bing)(bing)(bing)者(zhe)(zhe)宜(yi)慎(shen)(shen)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。 脈康 由(you)(you)安(an)妥明(ming)(ming)(ming)、芹菜(cai)籽(zi)及(ji)槐花(hua)米(mi)組(zu)(zu)成(cheng)(cheng)，有(you)(you)(you)(you)(you)(you)(you)(you)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)、降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)壓及(ji)改善血(xue)(xue)(xue)管(guan)(guan)(guan)脆(cui)性(xing)(xing)(xing)的(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)1片(pian)(pian)（0.3克(ke)(ke)(ke)），每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)3次(ci)(ci)(ci)(ci)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)后(hou)(hou)偶爾會(hui)引(yin)起肝(gan)(gan)(gan)功(gong)(gong)能(neng)(neng)(neng)損(sun)(sun)(sun)害(hai)，原(yuan)有(you)(you)(you)(you)(you)(you)(you)(you)肝(gan)(gan)(gan)功(gong)(gong)能(neng)(neng)(neng)減退者(zhe)(zhe)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)時宜(yi)小心(xin)(xin)(xin)(xin)。 安(an)絡寧 由(you)(you)安(an)妥明(ming)(ming)(ming)鋁(lv)鹽(yan)、何首(shou)(shou)烏、丹參、瓜萎、葛根(gen)、決明(ming)(ming)(ming)子、山楂及(ji)維生素(su)(su)(su)C等(deng)(deng)中西(xi)藥(yao)(yao)(yao)(yao)(yao)組(zu)(zu)成(cheng)(cheng)。適(shi)(shi)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)高(gao)(gao)脂(zhi)(zhi)(zhi)(zhi)(zhi)血(xue)(xue)(xue)癥(zheng)(zheng)伴(ban)冠心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)或(huo)(huo)(huo)(huo)高(gao)(gao)血(xue)(xue)(xue)壓的(de)(de)(de)(de)(de)(de)病(bing)(bing)(bing)人(ren)(ren)(ren)(ren)，有(you)(you)(you)(you)(you)(you)(you)(you)一(yi)定降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)和(he)(he)改善胸悶等(deng)(deng)癥(zheng)(zheng)狀(zhuang)的(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)3片(pian)(pian)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)3次(ci)(ci)(ci)(ci)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)后(hou)(hou)偶見(jian)肝(gan)(gan)(gan)功(gong)(gong)能(neng)(neng)(neng)損(sun)(sun)(sun)害(hai)原(yuan)有(you)(you)(you)(you)(you)(you)(you)(you)肝(gan)(gan)(gan)功(gong)(gong)能(neng)(neng)(neng)減退者(zhe)(zhe)慎(shen)(shen)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)或(huo)(huo)(huo)(huo)不(bu)(bu)(bu)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。 非諾(nuo)貝特 是(shi)(shi)一(yi)種(zhong)(zhong)(zhong)較強(qiang)效(xiao)(xiao)的(de)(de)(de)(de)(de)(de)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)新藥(yao)(yao)(yao)(yao)(yao)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)1片(pian)(pian)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)3次(ci)(ci)(ci)(ci)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)后(hou)(hou)可(ke)(ke)(ke)引(yin)起輕(qing)(qing)(qing)度(du)(du)(du)(du)(du)(du)肝(gan)(gan)(gan)功(gong)(gong)能(neng)(neng)(neng)損(sun)(sun)(sun)害(hai)，少(shao)數(shu)病(bing)(bing)(bing)人(ren)(ren)(ren)(ren)出現(xian)胃(wei)腸(chang)道癥(zheng)(zheng)狀(zhuang)或(huo)(huo)(huo)(huo)血(xue)(xue)(xue)清尿素(su)(su)(su)氮暫(zan)時性(xing)(xing)(xing)輕(qing)(qing)(qing)度(du)(du)(du)(du)(du)(du)增(zeng)高(gao)(gao)，停(ting)藥(yao)(yao)(yao)(yao)(yao)后(hou)(hou)可(ke)(ke)(ke)恢(hui)復(fu)正常。在服(fu)(fu)(fu)(fu)(fu)藥(yao)(yao)(yao)(yao)(yao)期(qi)間應(ying)定期(qi)復(fu)查(cha)肝(gan)(gan)(gan)、腎(shen)(shen)功(gong)(gong)能(neng)(neng)(neng)，原(yuan)有(you)(you)(you)(you)(you)(you)(you)(you)肝(gan)(gan)(gan)、腎(shen)(shen)功(gong)(gong)能(neng)(neng)(neng)減退者(zhe)(zhe)慎(shen)(shen)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，孕(yun)婦禁用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。 益多(duo)酯(zhi)(zhi)(zhi) 是(shi)(shi)安(an)妥明(ming)(ming)(ming)的(de)(de)(de)(de)(de)(de)衍(yan)生物(wu)(wu)(wu)，有(you)(you)(you)(you)(you)(you)(you)(you)明(ming)(ming)(ming)顯的(de)(de)(de)(de)(de)(de)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，還有(you)(you)(you)(you)(you)(you)(you)(you)很(hen)(hen)強(qiang)的(de)(de)(de)(de)(de)(de)抗微血(xue)(xue)(xue)栓(shuan)(shuan)(shuan)形(xing)成(cheng)(cheng)和(he)(he)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)血(xue)(xue)(xue)尿酸(suan)(suan)(suan)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)1粒，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)2次(ci)(ci)(ci)(ci)。偶見(jian)胃(wei)部不(bu)(bu)(bu)適(shi)(shi)、血(xue)(xue)(xue)清尿素(su)(su)(su)氮增(zeng)高(gao)(gao)，有(you)(you)(you)(you)(you)(you)(you)(you)潰瘍病(bing)(bing)(bing)和(he)(he)肝(gan)(gan)(gan)、腎(shen)(shen)功(gong)(gong)能(neng)(neng)(neng)有(you)(you)(you)(you)(you)(you)(you)(you)損(sun)(sun)(sun)害(hai)者(zhe)(zhe)慎(shen)(shen)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。 呋喃甲(jia)(jia)氫(qing)龍 為(wei)(wei)(wei)蛋(dan)白(bai)同(tong)化(hua)激(ji)素(su)(su)(su)，有(you)(you)(you)(you)(you)(you)(you)(you)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)膽(dan)固(gu)(gu)醇(chun)(chun)和(he)(he)甘油(you)三酯(zhi)(zhi)(zhi)的(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)效(xiao)(xiao)果明(ming)(ming)(ming)顯。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)1片(pian)(pian)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)3次(ci)(ci)(ci)(ci)。對(dui)(dui)(dui)(dui)肝(gan)(gan)(gan)臟(zang)(zang)(zang)(zang)(zang)功(gong)(gong)能(neng)(neng)(neng)有(you)(you)(you)(you)(you)(you)(you)(you)損(sun)(sun)(sun)害(hai)，并(bing)可(ke)(ke)(ke)使(shi)血(xue)(xue)(xue)糖增(zeng)高(gao)(gao)，原(yuan)有(you)(you)(you)(you)(you)(you)(you)(you)肝(gan)(gan)(gan)臟(zang)(zang)(zang)(zang)(zang)疾(ji)病(bing)(bing)(bing)或(huo)(huo)(huo)(huo)糖尿者(zhe)(zhe)慎(shen)(shen)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。 降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)平(ping) 由(you)(you)安(an)妥明(ming)(ming)(ming)、煙(yan)酸(suan)(suan)(suan)、肝(gan)(gan)(gan)樂、維生素(su)(su)(su)B6、康力(li)龍等(deng)(deng)組(zu)(zu)成(cheng)(cheng)，有(you)(you)(you)(you)(you)(you)(you)(you)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)及(ji)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)壓作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)1片(pian)(pian)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)3次(ci)(ci)(ci)(ci)，本藥(yao)(yao)(yao)(yao)(yao)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)效(xiao)(xiao)果明(ming)(ming)(ming)顯，但(dan)對(dui)(dui)(dui)(dui)肝(gan)(gan)(gan)臟(zang)(zang)(zang)(zang)(zang)有(you)(you)(you)(you)(you)(you)(you)(you)輕(qing)(qing)(qing)度(du)(du)(du)(du)(du)(du)損(sun)(sun)(sun)害(hai)。 煙(yan)酸(suan)(suan)(suan)肌(ji)(ji)(ji)(ji)醇(chun)(chun)酯(zhi)(zhi)(zhi) 是(shi)(shi)煙(yan)酸(suan)(suan)(suan)的(de)(de)(de)(de)(de)(de)酯(zhi)(zhi)(zhi)類(lei)(lei)，對(dui)(dui)(dui)(dui)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)血(xue)(xue)(xue)清甘油(you)三酯(zhi)(zhi)(zhi)有(you)(you)(you)(you)(you)(you)(you)(you)一(yi)定作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)1片(pian)(pian)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)3次(ci)(ci)(ci)(ci)，可(ke)(ke)(ke)有(you)(you)(you)(you)(you)(you)(you)(you)輕(qing)(qing)(qing)度(du)(du)(du)(du)(du)(du)惡心(xin)(xin)(xin)(xin)或(huo)(huo)(huo)(huo)面(mian)部潮藥(yao)(yao)(yao)(yao)(yao)等(deng)(deng)副(fu)反應(ying)。 安(an)妥明(ming)(ming)(ming) 降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)效(xiao)(xiao)果明(ming)(ming)(ming)顯。用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)法(fa)(fa)(fa)：口(kou)服(fu)(fu)(fu)(fu)(fu)每(mei)(mei)(mei)(mei)次(ci)(ci)(ci)(ci)1片(pian)(pian)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)3-4次(ci)(ci)(ci)(ci)。可(ke)(ke)(ke)有(you)(you)(you)(you)(you)(you)(you)(you)胃(wei)腸(chang)道副(fu)反應(ying)及(ji)暫(zan)時性(xing)(xing)(xing)肝(gan)(gan)(gan)功(gong)(gong)能(neng)(neng)(neng)減退，原(yuan)有(you)(you)(you)(you)(you)(you)(you)(you)肝(gan)(gan)(gan)臟(zang)(zang)(zang)(zang)(zang)病(bing)(bing)(bing)者(zhe)(zhe)應(ying)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)要(yao)(yao)小心(xin)(xin)(xin)(xin)。 血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)康 該(gai)藥(yao)(yao)(yao)(yao)(yao)是(shi)(shi)從(cong)紅曲中提煉制成(cheng)(cheng)的(de)(de)(de)(de)(de)(de)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)調節劑(ji)，含有(you)(you)(you)(you)(you)(you)(you)(you)洛伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)及(ji)多(duo)種(zhong)(zhong)(zhong)不(bu)(bu)(bu)飽(bao)和(he)(he)脂(zhi)(zhi)(zhi)(zhi)(zhi)肪酸(suan)(suan)(suan)和(he)(he)人(ren)(ren)(ren)(ren)體(ti)必需的(de)(de)(de)(de)(de)(de)氨(an)基酸(suan)(suan)(suan)，能(neng)(neng)(neng)明(ming)(ming)(ming)顯降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)TC、TG及(ji)LDL-C水平(ping)，對(dui)(dui)(dui)(dui)HDL-C有(you)(you)(you)(you)(you)(you)(you)(you)輕(qing)(qing)(qing)度(du)(du)(du)(du)(du)(du)升(sheng)(sheng)(sheng)(sheng)(sheng)高(gao)(gao)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)康可(ke)(ke)(ke)使(shi)粥(zhou)樣(yang)斑(ban)(ban)塊(kuai)病(bing)(bing)(bing)變(bian)有(you)(you)(you)(you)(you)(you)(you)(you)不(bu)(bu)(bu)同(tong)程度(du)(du)(du)(du)(du)(du)的(de)(de)(de)(de)(de)(de)減輕(qing)(qing)(qing)，預防(fang)(fang)脂(zhi)(zhi)(zhi)(zhi)(zhi)肪肝(gan)(gan)(gan)，降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)糖尿病(bing)(bing)(bing)人(ren)(ren)(ren)(ren)血(xue)(xue)(xue)糖，促進(jin)(jin)腦梗(geng)死(si)(si)病(bing)(bing)(bing)人(ren)(ren)(ren)(ren)恢(hui)復(fu)，并(bing)抑(yi)制肝(gan)(gan)(gan)臟(zang)(zang)(zang)(zang)(zang)合(he)成(cheng)(cheng)TC及(ji)減少(shao)LDL-C，無明(ming)(ming)(ming)顯副(fu)反應(ying)。每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)量(liang)為(wei)(wei)(wei)0.6-1.2克(ke)(ke)(ke)。對(dui)(dui)(dui)(dui)中度(du)(du)(du)(du)(du)(du)、低(di)(di)度(du)(du)(du)(du)(du)(du)升(sheng)(sheng)(sheng)(sheng)(sheng)高(gao)(gao)的(de)(de)(de)(de)(de)(de)高(gao)(gao)脂(zhi)(zhi)(zhi)(zhi)(zhi)血(xue)(xue)(xue)癥(zheng)(zheng)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)0.6克(ke)(ke)(ke)，口(kou)服(fu)(fu)(fu)(fu)(fu)，連用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)半年(nian)(nian)(nian)(nian)，效(xiao)(xiao)果明(ming)(ming)(ming)顯；對(dui)(dui)(dui)(dui)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)較高(gao)(gao)者(zhe)(zhe)，每(mei)(mei)(mei)(mei)日(ri)(ri)(ri)(ri)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)0.9-1.2克(ke)(ke)(ke)。 此(ci)外，菜(cai)薊(ji)、水飛薊(ji)素(su)(su)(su)等(deng)(deng)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)，有(you)(you)(you)(you)(you)(you)(you)(you)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)及(ji)保(bao)護(hu)肝(gan)(gan)(gan)臟(zang)(zang)(zang)(zang)(zang)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)，適(shi)(shi)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)高(gao)(gao)脂(zhi)(zhi)(zhi)(zhi)(zhi)血(xue)(xue)(xue)癥(zheng)(zheng)伴(ban)有(you)(you)(you)(you)(you)(you)(you)(you)肝(gan)(gan)(gan)功(gong)(gong)能(neng)(neng)(neng)減退的(de)(de)(de)(de)(de)(de)病(bing)(bing)(bing)人(ren)(ren)(ren)(ren)。 五、推(tui)(tui)廣應(ying)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)脂(zhi)(zhi)(zhi)(zhi)(zhi)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu) 有(you)(you)(you)(you)(you)(you)(you)(you)專(zhuan)家(jia)稱(cheng)，他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)對(dui)(dui)(dui)(dui)人(ren)(ren)(ren)(ren)類(lei)(lei)的(de)(de)(de)(de)(de)(de)貢獻將不(bu)(bu)(bu)亞于(yu)當年(nian)(nian)(nian)(nian)的(de)(de)(de)(de)(de)(de)青(qing)霉素(su)(su)(su)，推(tui)(tui)廣他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)被稱(cheng)為(wei)(wei)(wei)是(shi)(shi)一(yi)場“他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)革命”。但(dan)令人(ren)(ren)(ren)(ren)遺憾的(de)(de)(de)(de)(de)(de)是(shi)(shi)，目(mu)(mu)前(qian)我國許(xu)多(duo)基層醫院(yuan)還沒有(you)(you)(you)(you)(you)(you)(you)(you)推(tui)(tui)廣使(shi)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)，許(xu)多(duo)基層醫務人(ren)(ren)(ren)(ren)員(yuan)還不(bu)(bu)(bu)了解他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)。 他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)早(zao)(zao)在70年(nian)(nian)(nian)(nian)代首(shou)(shou)先由(you)(you)Endo等(deng)(deng)進(jin)(jin)行研究，他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)們發現(xian)，他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)的(de)(de)(de)(de)(de)(de)側(ce)鏈結構有(you)(you)(you)(you)(you)(you)(you)(you)與羥(qian)甲(jia)(jia)基戊二(er)(er)酰輔酶(mei)A（HMG-CoA）相似的(de)(de)(de)(de)(de)(de)部分(fen)，能(neng)(neng)(neng)競爭性(xing)(xing)(xing)地抑(yi)制膽(dan)固(gu)(gu)醇(chun)(chun)（CH），使(shi)其(qi)合(he)成(cheng)(cheng)減少(shao)，因而(er)(er)有(you)(you)(you)(you)(you)(you)(you)(you)清除高(gao)(gao)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)(zhi)(zhi)的(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)。 最近(jin)英國高(gao)(gao)血(xue)(xue)(xue)壓學(xue)會(hui)提出，他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)可(ke)(ke)(ke)作(zuo)(zuo)(zuo)(zuo)為(wei)(wei)(wei)防(fang)(fang)治心(xin)(xin)(xin)(xin)血(xue)(xue)(xue)管(guan)(guan)(guan)疾(ji)病(bing)(bing)(bing)的(de)(de)(de)(de)(de)(de)1級(ji)及(ji)2級(ji)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)。目(mu)(mu)前(qian)上(shang)市的(de)(de)(de)(de)(de)(de)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)種(zhong)(zhong)(zhong)類(lei)(lei)繁多(duo)，主要(yao)(yao)有(you)(you)(you)(you)(you)(you)(you)(you)：洛伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)、辛(xin)伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)、普伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)、氟(fu)伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)、阿(a)伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)、亞伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)、貝伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)、尼伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)及(ji)S-4522/ZD4522、Bay-W-4278等(deng)(deng)。 1993年(nian)(nian)(nian)(nian)，MARS試(shi)(shi)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)洛伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)80毫(hao)(hao)(hao)克(ke)(ke)(ke)與安(an)慰(wei)(wei)劑(ji)對(dui)(dui)(dui)(dui)比(bi)(bi)，服(fu)(fu)(fu)(fu)(fu)藥(yao)(yao)(yao)(yao)(yao)組(zu)(zu)患者(zhe)(zhe)總(zong)膽(dan)固(gu)(gu)醇(chun)(chun)、低(di)(di)密(mi)度(du)(du)(du)(du)(du)(du)脂(zhi)(zhi)(zhi)(zhi)(zhi)蛋(dan)白(bai)、載膽(dan)蛋(dan)白(bai)B分(fen)別下(xia)(xia)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)32%、38%、36%，高(gao)(gao)密(mi)度(du)(du)(du)(du)(du)(du)脂(zhi)(zhi)(zhi)(zhi)(zhi)蛋(dan)白(bai)升(sheng)(sheng)(sheng)(sheng)(sheng)高(gao)(gao)8.5%。試(shi)(shi)驗(yan)說明(ming)(ming)(ming)，洛伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)不(bu)(bu)(bu)僅能(neng)(neng)(neng)改善冠心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)及(ji)動脈硬化(hua)病(bing)(bing)(bing)變(bian)進(jin)(jin)展(zhan)，并(bing)可(ke)(ke)(ke)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)冠心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)、中風、心(xin)(xin)(xin)(xin)肌(ji)(ji)(ji)(ji)梗(geng)死(si)(si)的(de)(de)(de)(de)(de)(de)死(si)(si)亡率。 1994年(nian)(nian)(nian)(nian)，北歐用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)4S試(shi)(shi)驗(yan)觀察了4444例冠心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)患者(zhe)(zhe)，日(ri)(ri)(ri)(ri)服(fu)(fu)(fu)(fu)(fu)辛(xin)伐(fa)他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)20毫(hao)(hao)(hao)克(ke)(ke)(ke)，隨訪4.1年(nian)(nian)(nian)(nian)。服(fu)(fu)(fu)(fu)(fu)藥(yao)(yao)(yao)(yao)(yao)組(zu)(zu)與服(fu)(fu)(fu)(fu)(fu)安(an)慰(wei)(wei)劑(ji)組(zu)(zu)對(dui)(dui)(dui)(dui)比(bi)(bi)，總(zong)膽(dan)固(gu)(gu)醇(chun)(chun)、低(di)(di)密(mi)度(du)(du)(du)(du)(du)(du)脂(zhi)(zhi)(zhi)(zhi)(zhi)蛋(dan)白(bai)、甘油(you)三酯(zhi)(zhi)(zhi)分(fen)別下(xia)(xia)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)25%、35%、10%，高(gao)(gao)密(mi)度(du)(du)(du)(du)(du)(du)脂(zhi)(zhi)(zhi)(zhi)(zhi)蛋(dan)白(bai)升(sheng)(sheng)(sheng)(sheng)(sheng)高(gao)(gao)8%，死(si)(si)亡率大大下(xia)(xia)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)。 他(ta)(ta)(ta)(ta)(ta)(ta)(ta)(ta)汀(ting)(ting)(ting)(ting)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)物(wu)(wu)(wu)的(de)(de)(de)(de)(de)(de)毒(du)副(fu)作(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)主要(yao)(yao)為(wei)(wei)(wei)上(shang)腹(fu)痛(tong)(tong)、腹(fu)瀉(xie)、惡心(xin)(xin)(xin)(xin)、偶見(jian)有(you)(you)(you)(you)(you)(you)(you)(you)過敏反應(ying)、頭(tou)痛(tong)(tong)、視力(li)模糊。此(ci)類(lei)(lei)藥(yao)(yao)(yao)(yao)(yao)嚴禁用(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)(yong)于(yu)肝(gan)(gan)(gan)、腎(shen)(shen)功(gong)(gong)能(neng)(neng)(neng)不(bu)(bu)(bu)全(quan)者(zhe)(zhe)和(he)(he)孕(yun)婦。
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