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中藥配方顆粒研發提速

醫案日(ri)記 2023-06-14 12:50:17

中藥配方顆粒研(yan)發提(ti)速

本報訊(記者劉燕玲(ling))中藥配方顆粒研(yan)(yan)究開發(fa)與(yu)應用學(xue)術研(yan)(yan)討會日前召開。

據(ju)悉,國家中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)醫藥(yao)(yao)(yao)(yao)(yao)管理(li)局1993年即倡導(dao)并(bing)(bing)確立了(le)這一(yi)中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)藥(yao)(yao)(yao)(yao)(yao)飲(yin)片(pian)改革的(de)項(xiang)目,并(bing)(bing)將廣東一(yi)方(fang)(fang)(fang)制(zhi)藥(yao)(yao)(yao)(yao)(yao)有限公司(si)定為(wei)試點單(dan)位之一(yi),以(yi)(yi)后(hou)該項(xiang)目又(you)被列入原國家計委現代(dai)中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)藥(yao)(yao)(yao)(yao)(yao)高技(ji)術(shu)產業化推進項(xiang)目和(he)示范工(gong)(gong)程(cheng)項(xiang)目。研究(jiu)(jiu)人(ren)員以(yi)(yi)中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)醫藥(yao)(yao)(yao)(yao)(yao)理(li)論為(wei)指導(dao),分別進行了(le)中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)藥(yao)(yao)(yao)(yao)(yao)配方(fang)(fang)(fang)顆(ke)粒制(zhi)備工(gong)(gong)藝和(he)質(zhi)(zhi)量控(kong)制(zhi)、與(yu)中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)藥(yao)(yao)(yao)(yao)(yao)飲(yin)片(pian)臨(lin)床(chuang)用(yong)(yong)藥(yao)(yao)(yao)(yao)(yao)量以(yi)(yi)及(ji)療效的(de)比較(jiao)、中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)藥(yao)(yao)(yao)(yao)(yao)復(fu)方(fang)(fang)(fang)單(dan)煎與(yu)合煎藥(yao)(yao)(yao)(yao)(yao)效學的(de)比較(jiao)、質(zhi)(zhi)量穩定性(xing)、毒理(li)學等(deng)(deng)多項(xiang)研究(jiu)(jiu),完(wan)成(cheng)(cheng)(cheng)了(le)對(dui)(dui)462種中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)藥(yao)(yao)(yao)(yao)(yao)的(de)提取、濃縮、噴霧(wu)干燥、制(zhi)粒工(gong)(gong)藝研究(jiu)(jiu),并(bing)(bing)制(zhi)定了(le)工(gong)(gong)藝規(gui)程(cheng)、質(zhi)(zhi)量標(biao)準和(he)薄層色譜鑒(jian)別圖譜。同時還完(wan)成(cheng)(cheng)(cheng)了(le)上千(qian)批次的(de)產品(pin)質(zhi)(zhi)量穩定考察和(he)與(yu)飲(yin)片(pian)臨(lin)床(chuang)用(yong)(yong)藥(yao)(yao)(yao)(yao)(yao)的(de)對(dui)(dui)比折算研究(jiu)(jiu),以(yi)(yi)及(ji)對(dui)(dui)逍遙散等(deng)(deng)10個(ge)復(fu)方(fang)(fang)(fang)單(dan)煎與(yu)合煎藥(yao)(yao)(yao)(yao)(yao)效學的(de)比較(jiao)研究(jiu)(jiu)。近年來(lai)又(you)完(wan)成(cheng)(cheng)(cheng)了(le)對(dui)(dui)200個(ge)品(pin)種新工(gong)(gong)藝、新設備、新技(ji)術(shu)的(de)研究(jiu)(jiu);建立了(le)對(dui)(dui)原材料、半成(cheng)(cheng)(cheng)品(pin)和(he)成(cheng)(cheng)(cheng)品(pin)全過程(cheng)質(zhi)(zhi)量監控(kong)和(he)檢測的(de)方(fang)(fang)(fang)法;解(jie)決(jue)了(le)配方(fang)(fang)(fang)顆(ke)粒在不具(ju)備飲(yin)片(pian)外形后(hou)品(pin)種的(de)真偽鑒(jian)別和(he)質(zhi)(zhi)量優(you)劣的(de)評價(jia)問題。中(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)(zhong)藥(yao)(yao)(yao)(yao)(yao)配方(fang)(fang)(fang)顆(ke)粒已為(wei)越來(lai)越多的(de)群眾(zhong)所接受。自(zi)1998年“一(yi)方(fang)(fang)(fang)制(zhi)藥(yao)(yao)(yao)(yao)(yao)”啟動(dong)國際(ji)市場(chang)后(hou),已與(yu)美、加、澳(ao)以(yi)(yi)及(ji)香港等(deng)(deng)建立了(le)穩定的(de)合作關系,國際(ji)市場(chang)銷(xiao)售收(shou)入以(yi)(yi)每(mei)年100%以(yi)(yi)上的(de)速度(du)增(zeng)長。

新綠色(se)中藥(yao)配方(fang)顆(ke)粒是怎么智能抓藥(yao)的?

公司多年持續投資研發的(de)(de)配(pei)方(fang)顆粒自(zi)動發藥(yao)(yao)(yao)機系統,采用獨(du)特(te)的(de)(de)方(fang)式計量各(ge)味中藥(yao)(yao)(yao),從下藥(yao)(yao)(yao)到最后(hou)將藥(yao)(yao)(yao)封裝成盒,整個過程都在一(yi)次(ci)性使(shi)用的(de)(de)藥(yao)(yao)(yao)杯中完成,期(qi)間不用任何人工干預,保證了中藥(yao)(yao)(yao)的(de)(de)無(wu)交(jiao)叉污染(ran)。

一(yi)方中藥顆粒沖劑與傳統熬制服(fu)用(yong)中藥相比的(de)優勢具體有哪些?

建議:中(zhong)(zhong)藥(yao)配方顆粒(li)劑(ji)(ji)即(ji)把傳(chuan)統中(zhong)(zhong)藥(yao)材進行深加工,不(bu)(bu)(bu)保(bao)留藥(yao)材的(de)(de)(de)外形,只(zhi)提取有效(xiao)成(cheng)(cheng)分后(hou)制(zhi)成(cheng)(cheng)的(de)(de)(de)顆粒(li)狀劑(ji)(ji)型(xing),將(jiang)顆粒(li)貯存在特殊的(de)(de)(de)容器(qi)(qi)中(zhong)(zhong),在醫(yi)生開出處方后(hou),藥(yao)劑(ji)(ji)科(ke)會按(an)處方的(de)(de)(de)品種(zhong)(zhong)進行配伍,將(jiang)每(mei)種(zhong)(zhong)不(bu)(bu)(bu)同的(de)(de)(de)飲片(pian)顆粒(li)通過(guo)自動調(diao)配設備混合(he)一(yi)(yi)(yi)起,裝到包裝袋中(zhong)(zhong),每(mei)付(fu)中(zhong)(zhong)藥(yao)兩袋,患者只(zhi)需像感冒(mao)沖(chong)劑(ji)(ji)一(yi)(yi)(yi)樣(yang)沖(chong)調(diao)即(ji)可(ke)服(fu)(fu)用(yong),具有攜帶、服(fu)(fu)用(yong)方便,便于(yu)醫(yi)院調(diao)劑(ji)(ji)等優點。而對于(yu)患者來說,由于(yu)免去了熬藥(yao)的(de)(de)(de)麻(ma)煩,依(yi)從(cong)性(xing)(xing)(xing)(xing)明顯加強,大大方便了患者服(fu)(fu)用(yong),受(shou)到醫(yi)生和(he)患者的(de)(de)(de)認可(ke)。 免煎(jian)(jian)(jian)顆粒(li)劑(ji)(ji)的(de)(de)(de)制(zhi)藥(yao)工藝(yi)對有效(xiao)成(cheng)(cheng)分的(de)(de)(de)提取亦明顯優于(yu)自煎(jian)(jian)(jian)方法(fa)(fa)。 中(zhong)(zhong)藥(yao)配方顆粒(li)與傳(chuan)統中(zhong)(zhong)藥(yao)飲片(pian)和(he)中(zhong)(zhong)成(cheng)(cheng)藥(yao)相比具有很多優點。”用(yong)中(zhong)(zhong)藥(yao)飲片(pian)煎(jian)(jian)(jian)成(cheng)(cheng)湯(tang)劑(ji)(ji)服(fu)(fu)用(yong)不(bu)(bu)(bu)但費時,而且患者自己(ji)煎(jian)(jian)(jian)藥(yao)受(shou)到許多條件的(de)(de)(de)限制(zhi),比如煎(jian)(jian)(jian)煮時間、煎(jian)(jian)(jian)煮器(qi)(qi)皿、加水量、火候、先煎(jian)(jian)(jian)與后(hou)下等煎(jian)(jian)(jian)藥(yao)方法(fa)(fa)很難掌(zhang)握(wo),完全憑經(jing)驗,主觀(guan)隨(sui)意(yi)性(xing)(xing)(xing)(xing)很強,而且缺乏可(ke)靠的(de)(de)(de)質量檢測和(he)監(jian)控手段(duan),諸多不(bu)(bu)(bu)確(que)定(ding)(ding)性(xing)(xing)(xing)(xing)因(yin)素使臨床(chuang)療效(xiao)無法(fa)(fa)得到保(bao)證(zheng)(zheng)。而中(zhong)(zhong)成(cheng)(cheng)藥(yao)一(yi)(yi)(yi)般只(zhi)是針對特定(ding)(ding)人群、特定(ding)(ding)病種(zhong)(zhong),無法(fa)(fa)隨(sui)癥加減,臨床(chuang)用(yong)藥(yao)有很大的(de)(de)(de)局限性(xing)(xing)(xing)(xing)。中(zhong)(zhong)藥(yao)配方顆粒(li)則既保(bao)持(chi)了中(zhong)(zhong)藥(yao)飲片(pian)的(de)(de)(de)藥(yao)性(xing)(xing)(xing)(xing)和(he)藥(yao)效(xiao),可(ke)供中(zhong)(zhong)醫(yi)臨床(chuang)辯證(zheng)(zheng)施治、隨(sui)癥加減,個體化給藥(yao),又具有直接(jie)沖(chong)服(fu)(fu)、攜帶方便、衛生安全、療效(xiao)確(que)切以及質量穩定(ding)(ding)、均一(yi)(yi)(yi)和(he)可(ke)控等優點,在很大程度(du)上改變了中(zhong)(zhong)藥(yao)飲片(pian)目前存在諸多不(bu)(bu)(bu)確(que)定(ding)(ding)性(xing)(xing)(xing)(xing)和(he)隨(sui)意(yi)性(xing)(xing)(xing)(xing)的(de)(de)(de)情況(kuang)。

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