加減八味丸湯

處方 : 熟(shu)地1兩，山茱萸(yu)5錢(qian)(qian)，丹皮5錢(qian)(qian)，澤(ze)瀉(xie)2錢(qian)(qian)，茯苓3錢(qian)(qian)，山藥5錢(qian)(qian)，麥(mai)冬(dong)5錢(qian)(qian)，北五味1錢(qian)(qian)，肉桂2錢(qian)(qian)。

功能主治 : 男子腎火虛弱，一交接婦女，則耳中作痛，或(huo)癢(yang)發不已，或(huo)流臭水，以(yi)涼物投入則快者。

用法用量 : 水煎服。

摘錄 : 《辨證錄》卷三

清下湯簡介

目錄(lu)1拼(pin)音(yin)2《醫方簡義(yi)》卷三 2.1方名2.2組成2.3主治(zhi)2.4清下(xia)湯(tang)(tang)的用(yong)(yong)法用(yong)(yong)量2.5加(jia)減2.6各(ge)家(jia)論述 附：1古籍中的清下(xia)湯(tang)(tang) 1拼(pin)音(yin) qīng xià tāng

2《醫方簡義》卷三

2.1方名

清下湯

2.2組成

大黃（醋炒）3錢(qian)，牡(mu)丹皮3錢(qian)，歸身(shen)3錢(qian)，白芍1錢(qian)，苦(ku)參1錢(qian)，焦梔(zhi)子3錢(qian)，生甘草8分，北細(xi)辛(xin)2分，通(tong)草1錢(qian)5分。

2.3主治

大(da)小便血(xue)(xue)，血(xue)(xue)淋，舌上出血(xue)(xue)。

2.4清下湯的用法用量

上加鮮(xian)荷葉1片，水煎(jian)服。如無鮮(xian)荷葉，以藕1斤煎(jian)湯代水。

2.5加減

小便尿血(xue)，加(jia)琥珀(po)1錢(qian)(qian)，滑石(shi)3錢(qian)(qian)；血(xue)淋(lin)癥小腹滯痛，濕熱內蘊，加(jia)琥珀(po)1錢(qian)(qian)，滑石(shi)、瞿麥各3錢(qian)(qian)，去細(xi)辛；舌上無故出血(xue)，加(jia)川連(lian)8分，炒蒲黃7分，烏賊骨1錢(qian)(qian)，去細(xi)辛；痰血(xue)交(jiao)互，去苦參(can)、細(xi)辛，加(jia)姜半(ban)夏1錢(qian)(qian)，川貝2錢(qian)(qian)，真化橘紅1錢(qian)(qian)。

2.6各家論述

方中用(yong)大黃以入陽(yang)明經驅瘀蕩(dang)熱(re)(re)，丹皮溶血中之(zhi)熱(re)(re)，白芍瀉肝，歸身養血，細辛溫(wen)經，勿使寒涼(liang)傷血，苦參清濕(shi)火(huo)，梔子泄三焦之(zhi)火(huo)，通草滲濕(shi)清熱(re)(re)，生(sheng)甘草解毒以和諸藥之(zhi)性(xing)。

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附(fu)桂八味丸簡介

目錄(lu)1拼(pin)音2英文(wen)參考3附(fu)桂(gui)(gui)八味丸(wan)說明(ming)書 3.1藥品(pin)名(ming)稱3.2藥品(pin)漢語拼(pin)音3.3附(fu)桂(gui)(gui)八味丸(wan)的(de)別名(ming)3.4分類3.5劑型3.6附(fu)桂(gui)(gui)八味丸(wan)的(de)主要成(cheng)份3.7附(fu)桂(gui)(gui)八味丸(wan)的(de)藥理作用(yong)3.8附(fu)桂(gui)(gui)八味丸(wan)的(de)適應證3.9注意(yi)事項3.10附(fu)桂(gui)(gui)八味丸(wan)的(de)用(yong)法用(yong)量3.11專(zhuan)家點評1拼(pin)音 fù guì bā wèi wán

2英文參考 Fuguei Bawei wan

3附桂八味丸說明書

3.1藥品名稱

附桂八味丸

3.2藥品漢語拼音

Fuguei Bawei wan

3.3附桂八味丸的別名

崔氏八(ba)味丸；八(ba)味丸；八(ba)味地黃丸

3.4分類

內分泌(mi)系統藥物 > 中(zhong)成(cheng)藥

3.5劑型

大蜜丸(wan)：每(mei)丸(wan)9g，每(mei)盒(he)10丸(wan)；片劑：每(mei)片含生藥0.5g，每(mei)瓶(ping)裝500片；口(kou)服液：每(mei)支10ml，每(mei)盒(he)裝10支；膠(jiao)囊：每(mei)粒含生藥0.5g，每(mei)瓶(ping)裝100粒。

3.6附桂八味丸的主要成份

附子、肉桂、熟地(di)黃、山(shan)藥、山(shan)茱萸(yu)、澤(ze)瀉(xie)、茯(fu)苓、牡丹皮。

3.7附桂八味丸的藥理作用

降(jiang)血糖，降(jiang)血脂，增(zeng)強免疫，改善內分泌(mi)，清除自由基(ji)，利尿，降(jiang)血壓等作用。

1.藥(yao)(yao)理作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong) （1）降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)血(xue)(xue)(xue)糖(tang) 以(yi)5倍(bei)或10倍(bei)于(yu)(yu)人(ren)(ren)常用(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)(liang)(liang)(liang)給(gei)成(cheng)(cheng)(cheng)年大(da)(da)(da)鼠(shu)(shu)(shu)服(fu)(fu)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)，看到(dao)了(le)糖(tang)耐量(liang)(liang)(liang)(liang)(liang)曲線的(de)(de)(de)(de)(de)(de)(de)(de)(de)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)，血(xue)(xue)(xue)糖(tang)值(zhi)的(de)(de)(de)(de)(de)(de)(de)(de)(de)恢(hui)復更迅速(su)。本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)老(lao)年大(da)(da)(da)鼠(shu)(shu)(shu)或小鼠(shu)(shu)(shu)因老(lao)化而(er)不斷降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)的(de)(de)(de)(de)(de)(de)(de)(de)(de)糖(tang)同(tong)化功(gong)能(neng)(neng)(neng)(neng)(neng)，改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)胰島分(fen)(fen)(fen)泌胰島素(su)(su)(su)(su)(su)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。用(yong)(yong)(yong)(yong)(yong)(yong)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)飲片制(zhi)成(cheng)(cheng)(cheng)的(de)(de)(de)(de)(de)(de)(de)(de)(de)散(san)劑(ji)(ji)及(ji)組成(cheng)(cheng)(cheng)該方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)的(de)(de)(de)(de)(de)(de)(de)(de)(de)各(ge)種(zhong)單(dan)味(wei)生(sheng)藥(yao)(yao)散(san)劑(ji)(ji)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)大(da)(da)(da)鼠(shu)(shu)(shu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)STZ（鏈尿(niao)(niao)(niao)(niao)(niao)(niao)菌(jun)素(su)(su)(su)(su)(su)）糖(tang)尿(niao)(niao)(niao)(niao)(niao)(niao)病(bing)(bing)(bing)模型(xing)的(de)(de)(de)(de)(de)(de)(de)(de)(de)飲水量(liang)(liang)(liang)(liang)(liang)、排尿(niao)(niao)(niao)(niao)(niao)(niao)量(liang)(liang)(liang)(liang)(liang)及(ji)尿(niao)(niao)(niao)(niao)(niao)(niao)糖(tang)量(liang)(liang)(liang)(liang)(liang)均(jun)呈(cheng)(cheng)抑(yi)(yi)制(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，顆粒(li)劑(ji)(ji)僅有(you)(you)(you)(you)(you)(you)(you)(you)(you)抑(yi)(yi)制(zhi)尿(niao)(niao)(niao)(niao)(niao)(niao)糖(tang)量(liang)(liang)(liang)(liang)(liang)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，單(dan)味(wei)藥(yao)(yao)中(zhong)(zhong)唯山茱萸對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)飲水量(liang)(liang)(liang)(liang)(liang)等(deng)(deng)呈(cheng)(cheng)抑(yi)(yi)制(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。（2）增(zeng)強(qiang)(qiang)(qiang)免(mian)疫(yi)功(gong)能(neng)(neng)(neng)(neng)(neng) 增(zeng)強(qiang)(qiang)(qiang)結(jie)(jie)核(he)菌(jun)素(su)(su)(su)(su)(su)反(fan)應，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)結(jie)(jie)核(he)菌(jun)素(su)(su)(su)(su)(su)反(fan)應為陰性(xing)(xing)(xing)(xing)(xing)或可(ke)疑陽(yang)性(xing)(xing)(xing)(xing)(xing)的(de)(de)(de)(de)(de)(de)(de)(de)(de)非免(mian)疫(yi)性(xing)(xing)(xing)(xing)(xing)疾(ji)(ji)(ji)病(bing)(bing)(bing)患者(zhe)13例，服(fu)(fu)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)后(hou)皮(pi)(pi)內反(fan)應表明(ming)結(jie)(jie)核(he)菌(jun)素(su)(su)(su)(su)(su)反(fan)應增(zeng)強(qiang)(qiang)(qiang)。另(ling)在(zai)65歲(sui)以(yi)上(shang)(shang)(shang)老(lao)人(ren)(ren)經(jing)辨證(zheng)(zheng)為八味(wei)丸(wan)(wan)(wan)證(zheng)(zheng)組，服(fu)(fu)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)后(hou)結(jie)(jie)核(he)菌(jun)素(su)(su)(su)(su)(su)反(fan)應也(ye)有(you)(you)(you)(you)(you)(you)(you)(you)(you)明(ming)顯(xian)(xian)的(de)(de)(de)(de)(de)(de)(de)(de)(de)增(zeng)強(qiang)(qiang)(qiang)。體(ti)(ti)(ti)(ti)(ti)外實(shi)(shi)驗(yan)(yan)見(jian)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)可(ke)提(ti)高(gao)(gao)(gao)小鼠(shu)(shu)(shu)巨噬細(xi)(xi)(xi)胞(bao)功(gong)能(neng)(neng)(neng)(neng)(neng)，使(shi)(shi)吞噬率(lv)和(he)(he)(he)吞噬指(zhi)數均(jun)高(gao)(gao)(gao)于(yu)(yu)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)照(zhao)組，并(bing)使(shi)(shi)溶血(xue)(xue)(xue)素(su)(su)(su)(su)(su)抗(kang)體(ti)(ti)(ti)(ti)(ti)形(xing)成(cheng)(cheng)(cheng)顯(xian)(xian)著(zhu)(zhu)增(zeng)加。其(qi)(qi)生(sheng)理鹽水提(ti)取(qu)液(ye)未見(jian)有(you)(you)(you)(you)(you)(you)(you)(you)(you)明(ming)顯(xian)(xian)的(de)(de)(de)(de)(de)(de)(de)(de)(de) *** 因子(zi)(zi)，但對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)老(lao)年人(ren)(ren)淋巴細(xi)(xi)(xi)胞(bao)亞群的(de)(de)(de)(de)(de)(de)(de)(de)(de)比(bi)例有(you)(you)(you)(you)(you)(you)(you)(you)(you)調(diao)節作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，并(bing)能(neng)(neng)(neng)(neng)(neng)防止老(lao)年人(ren)(ren)IgG低(di)(di)(di)下，使(shi)(shi)IgM上(shang)(shang)(shang)升(sheng)及(ji)提(ti)高(gao)(gao)(gao)補體(ti)(ti)(ti)(ti)(ti)活(huo)(huo)性(xing)(xing)(xing)(xing)(xing)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)主訴倦(juan)怠(dai)的(de)(de)(de)(de)(de)(de)(de)(de)(de)30例門(men)診病(bing)(bing)(bing)人(ren)(ren)用(yong)(yong)(yong)(yong)(yong)(yong)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)后(hou)發(fa)(fa)現自(zi)(zi)(zi)(zi)然(ran)殺(sha)傷細(xi)(xi)(xi)胞(bao)活(huo)(huo)性(xing)(xing)(xing)(xing)(xing)的(de)(de)(de)(de)(de)(de)(de)(de)(de)CD16（P＜0.05＝和(he)(he)(he)CD57（P＜0.01）陽(yang)性(xing)(xing)(xing)(xing)(xing)細(xi)(xi)(xi)胞(bao)數（淋巴細(xi)(xi)(xi)胞(bao)中(zhong)(zhong)一類）明(ming)顯(xian)(xian)上(shang)(shang)(shang)升(sheng)。（3）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)谷胱甘肽(tai)代(dai)謝(xie)(xie)(xie)的(de)(de)(de)(de)(de)(de)(de)(de)(de)影(ying)響(xiang)(xiang)(xiang) 探討給(gei)藥(yao)(yao)后(hou)大(da)(da)(da)鼠(shu)(shu)(shu)機體(ti)(ti)(ti)(ti)(ti)內谷胱甘肽(tai)代(dai)謝(xie)(xie)(xie)，還(huan)原型(xing)谷胱甘肽(tai)（GSH），氧(yang)(yang)(yang)化型(xing)谷胱甘肽(tai)（GSSG）的(de)(de)(de)(de)(de)(de)(de)(de)(de)含(han)量(liang)(liang)(liang)(liang)(liang)，GSH和(he)(he)(he)GSSG分(fen)(fen)(fen)別自(zi)(zi)(zi)(zi)晶(jing)(jing)體(ti)(ti)(ti)(ti)(ti)、血(xue)(xue)(xue)漿(jiang)、肝(gan)、腎、腦(nao)(nao)、精巢中(zhong)(zhong)進行熒光法測定(ding)，結(jie)(jie)果顯(xian)(xian)示動(dong)(dong)(dong)物(wu)實(shi)(shi)驗(yan)(yan)白(bai)(bai)內障(zhang)時(shi)(shi)晶(jing)(jing)體(ti)(ti)(ti)(ti)(ti)GSH和(he)(he)(he)GSSG顯(xian)(xian)著(zhu)(zhu)減少(shao)，導致(zhi)(zhi)透(tou)明(ming)度(du)(du)(du)發(fa)(fa)生(sheng)改(gai)(gai)(gai)(gai)(gai)(gai)變(bian)(bian)。金(jin)匱(kui)腎氣(qi)(qi)丸(wan)(wan)(wan)可(ke)預防晶(jing)(jing)體(ti)(ti)(ti)(ti)(ti)中(zhong)(zhong)GSH量(liang)(liang)(liang)(liang)(liang)隨年齡(ling)增(zeng)長而(er)下降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)導致(zhi)(zhi)的(de)(de)(de)(de)(de)(de)(de)(de)(de)白(bai)(bai)內障(zhang)。本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)還(huan)能(neng)(neng)(neng)(neng)(neng)使(shi)(shi)白(bai)(bai)內障(zhang)眼病(bing)(bing)(bing)患者(zhe)水晶(jing)(jing)體(ti)(ti)(ti)(ti)(ti)GSH和(he)(he)(he)GSSG呈(cheng)(cheng)顯(xian)(xian)著(zhu)(zhu)增(zeng)加，提(ti)示本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)還(huan)有(you)(you)(you)(you)(you)(you)(you)(you)(you)治療作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。另(ling)外有(you)(you)(you)(you)(you)(you)(you)(you)(you)實(shi)(shi)驗(yan)(yan)報(bao)(bao)道(dao)(dao)睪丸(wan)(wan)(wan)中(zhong)(zhong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)GSH和(he)(he)(he)GSSG本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)組也(ye)增(zeng)加，谷胱甘肽(tai)與DNA的(de)(de)(de)(de)(de)(de)(de)(de)(de)合成(cheng)(cheng)(cheng)有(you)(you)(you)(you)(you)(you)(you)(you)(you)聯系，因而(er)推測本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)激素(su)(su)(su)(su)(su)及(ji) *** 的(de)(de)(de)(de)(de)(de)(de)(de)(de)形(xing)成(cheng)(cheng)(cheng)有(you)(you)(you)(you)(you)(you)(you)(you)(you)一定(ding)的(de)(de)(de)(de)(de)(de)(de)(de)(de)影(ying)響(xiang)(xiang)(xiang)。（4）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)血(xue)(xue)(xue)脂(zhi)(zhi)(zhi)和(he)(he)(he)動(dong)(dong)(dong)脈(mo)粥(zhou)樣(yang)(yang)硬(ying)化的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong) 本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)能(neng)(neng)(neng)(neng)(neng)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)鵪(an)鶉食餌性(xing)(xing)(xing)(xing)(xing)高(gao)(gao)(gao)脂(zhi)(zhi)(zhi)血(xue)(xue)(xue)癥(zheng)包括高(gao)(gao)(gao)甘油三酯(zhi)和(he)(he)(he)高(gao)(gao)(gao)膽(dan)固(gu)(gu)醇(chun)(chun)，有(you)(you)(you)(you)(you)(you)(you)(you)(you)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)飼(si)(si)高(gao)(gao)(gao)膽(dan)固(gu)(gu)醇(chun)(chun)的(de)(de)(de)(de)(de)(de)(de)(de)(de)ddy小鼠(shu)(shu)(shu)肝(gan)、心及(ji)主動(dong)(dong)(dong)脈(mo)脂(zhi)(zhi)(zhi)質(zhi)(zhi)(zhi)(zhi)的(de)(de)(de)(de)(de)(de)(de)(de)(de)傾向，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)衰(shuai)老(lao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)脂(zhi)(zhi)(zhi)質(zhi)(zhi)(zhi)(zhi)代(dai)謝(xie)(xie)(xie)及(ji)長期(qi)投予(yu)乙醇(chun)(chun)所(suo)致(zhi)(zhi)的(de)(de)(de)(de)(de)(de)(de)(de)(de)肝(gan)脂(zhi)(zhi)(zhi)質(zhi)(zhi)(zhi)(zhi)代(dai)謝(xie)(xie)(xie)低(di)(di)(di)下有(you)(you)(you)(you)(you)(you)(you)(you)(you)明(ming)顯(xian)(xian)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。長期(qi)給(gei)藥(yao)(yao)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)飼(si)(si)高(gao)(gao)(gao)膽(dan)固(gu)(gu)醇(chun)(chun)的(de)(de)(de)(de)(de)(de)(de)(de)(de)ddy小鼠(shu)(shu)(shu)主動(dong)(dong)(dong)脈(mo)鈣、磷、鎂含(han)量(liang)(liang)(liang)(liang)(liang)及(ji)34鈣結(jie)(jie)合量(liang)(liang)(liang)(liang)(liang)還(huan)有(you)(you)(you)(you)(you)(you)(you)(you)(you)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)傾向，同(tong)時(shi)(shi)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)其(qi)(qi)膠原量(liang)(liang)(liang)(liang)(liang)，說(shuo)明(ming)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)具有(you)(you)(you)(you)(you)(you)(you)(you)(you)防止動(dong)(dong)(dong)脈(mo)粥(zhou)樣(yang)(yang)硬(ying)化作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。另(ling)實(shi)(shi)驗(yan)(yan)報(bao)(bao)道(dao)(dao)服(fu)(fu)用(yong)(yong)(yong)(yong)(yong)(yong)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)后(hou)高(gao)(gao)(gao)密度(du)(du)(du)脂(zhi)(zhi)(zhi)蛋(dan)白(bai)(bai)明(ming)顯(xian)(xian)增(zeng)加。同(tong)時(shi)(shi)動(dong)(dong)(dong)脈(mo)硬(ying)化指(zhi)數也(ye)有(you)(you)(you)(you)(you)(you)(you)(you)(you)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，因此本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)動(dong)(dong)(dong)脈(mo)粥(zhou)樣(yang)(yang)硬(ying)化的(de)(de)(de)(de)(de)(de)(de)(de)(de)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)也(ye)會產(chan)生(sheng)良好(hao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)影(ying)響(xiang)(xiang)(xiang)。（5）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)活(huo)(huo)性(xing)(xing)(xing)(xing)(xing)自(zi)(zi)(zi)(zi)由基(ji)(ji)(ji)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong) 活(huo)(huo)性(xing)(xing)(xing)(xing)(xing)自(zi)(zi)(zi)(zi)由基(ji)(ji)(ji)產(chan)生(sheng)是(shi)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)外來(lai)異物(wu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)一種(zhong)反(fan)應。對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)殺(sha)滅異物(wu)起到(dao)免(mian)疫(yi)保(bao)護作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，但產(chan)生(sheng)過(guo)(guo)多導致(zhi)(zhi)膜脂(zhi)(zhi)(zhi)質(zhi)(zhi)(zhi)(zhi)過(guo)(guo)氧(yang)(yang)(yang)化，與衰(shuai)老(lao)、自(zi)(zi)(zi)(zi)身免(mian)疫(yi)性(xing)(xing)(xing)(xing)(xing)疾(ji)(ji)(ji)病(bing)(bing)(bing)及(ji)腫瘤等(deng)(deng)有(you)(you)(you)(you)(you)(you)(you)(you)(you)關。1989年姚氏報(bao)(bao)道(dao)(dao)金(jin)匱(kui)腎氣(qi)(qi)丸(wan)(wan)(wan)提(ti)高(gao)(gao)(gao)小鼠(shu)(shu)(shu)血(xue)(xue)(xue)液(ye)和(he)(he)(he)腦(nao)(nao)勻(yun)漿(jiang)過(guo)(guo)氧(yang)(yang)(yang)化物(wu)歧(qi)化酶（SOD）活(huo)(huo)性(xing)(xing)(xing)(xing)(xing)，降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)腦(nao)(nao)、腎上(shang)(shang)(shang)腺(xian)等(deng)(deng)組織脂(zhi)(zhi)(zhi)質(zhi)(zhi)(zhi)(zhi)過(guo)(guo)氧(yang)(yang)(yang)化產(chan)物(wu)丙二醛(quan)（MDA）含(han)量(liang)(liang)(liang)(liang)(liang)，具有(you)(you)(you)(you)(you)(you)(you)(you)(you)自(zi)(zi)(zi)(zi)由基(ji)(ji)(ji)及(ji)過(guo)(guo)氧(yang)(yang)(yang)化物(wu)的(de)(de)(de)(de)(de)(de)(de)(de)(de)清(qing)除(chu)(chu)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。還(huan)有(you)(you)(you)(you)(you)(you)(you)(you)(you)報(bao)(bao)道(dao)(dao)金(jin)匱(kui)腎氣(qi)(qi)丸(wan)(wan)(wan)可(ke)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)老(lao)年鼠(shu)(shu)(shu)皮(pi)(pi)膚及(ji)血(xue)(xue)(xue)清(qing)MDA，提(ti)高(gao)(gao)(gao)SOD，促進自(zi)(zi)(zi)(zi)由基(ji)(ji)(ji)代(dai)謝(xie)(xie)(xie)，減少(shao)自(zi)(zi)(zi)(zi)由基(ji)(ji)(ji)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)細(xi)(xi)(xi)胞(bao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)損傷作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，減少(shao)高(gao)(gao)(gao)脂(zhi)(zhi)(zhi)血(xue)(xue)(xue)癥(zheng)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)脂(zhi)(zhi)(zhi)質(zhi)(zhi)(zhi)(zhi)過(guo)(guo)氧(yang)(yang)(yang)化作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，從而(er)使(shi)(shi)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)具治療疾(ji)(ji)(ji)病(bing)(bing)(bing)及(ji)抗(kang)衰(shuai)老(lao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。（6）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)末梢(shao)循(xun)環(huan)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong) 隨著(zhu)(zhu)大(da)(da)(da)鼠(shu)(shu)(shu)老(lao)化，高(gao)(gao)(gao)比(bi)重的(de)(de)(de)(de)(de)(de)(de)(de)(de)細(xi)(xi)(xi)胞(bao)增(zeng)加，變(bian)(bian)形(xing)能(neng)(neng)(neng)(neng)(neng)力降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)，給(gei)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)后(hou)能(neng)(neng)(neng)(neng)(neng)明(ming)顯(xian)(xian)抑(yi)(yi)制(zhi)其(qi)(qi)變(bian)(bian)形(xing)能(neng)(neng)(neng)(neng)(neng)力的(de)(de)(de)(de)(de)(de)(de)(de)(de)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)。同(tong)時(shi)(shi)測定(ding)紅細(xi)(xi)(xi)胞(bao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)ATP含(han)量(liang)(liang)(liang)(liang)(liang)、脂(zhi)(zhi)(zhi)質(zhi)(zhi)(zhi)(zhi)膜組成(cheng)(cheng)(cheng)及(ji)表面電荷等(deng)(deng)，本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)也(ye)有(you)(you)(you)(you)(you)(you)(you)(you)(you)良好(hao)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)65歲(sui)以(yi)上(shang)(shang)(shang)手(shou)足麻木的(de)(de)(de)(de)(de)(de)(de)(de)(de)患者(zhe)測標(biao)志末梢(shao)血(xue)(xue)(xue)流量(liang)(liang)(liang)(liang)(liang)的(de)(de)(de)(de)(de)(de)(de)(de)(de)指(zhi)尖容積(ji)脈(mo)搏(bo)，所(suo)有(you)(you)(you)(you)(you)(you)(you)(you)(you)患者(zhe)均(jun)增(zeng)加，服(fu)(fu)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)后(hou)明(ming)顯(xian)(xian)下降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)，癥(zheng)狀緩解。對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)糖(tang)尿(niao)(niao)(niao)(niao)(niao)(niao)病(bing)(bing)(bing)人(ren)(ren)的(de)(de)(de)(de)(de)(de)(de)(de)(de)治療中(zhong)(zhong)也(ye)可(ke)見(jian)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)微循(xun)環(huan)系統(tong)有(you)(you)(you)(you)(you)(you)(you)(you)(you)較強(qiang)(qiang)(qiang)的(de)(de)(de)(de)(de)(de)(de)(de)(de)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。進一步(bu)實(shi)(shi)驗(yan)(yan)發(fa)(fa)現肉(rou)桂(gui)具有(you)(you)(you)(you)(you)(you)(you)(you)(you)中(zhong)(zhong)樞性(xing)(xing)(xing)(xing)(xing)及(ji)末梢(shao)性(xing)(xing)(xing)(xing)(xing)擴張血(xue)(xue)(xue)管作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)微循(xun)環(huan)，改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)感覺障(zhang)礙。（7）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)植(zhi)物(wu)神經(jing)系統(tong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)影(ying)響(xiang)(xiang)(xiang) 對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)有(you)(you)(you)(you)(you)(you)(you)(you)(you)療效的(de)(de)(de)(de)(de)(de)(de)(de)(de)糖(tang)尿(niao)(niao)(niao)(niao)(niao)(niao)病(bing)(bing)(bing)或非糖(tang)尿(niao)(niao)(niao)(niao)(niao)(niao)病(bing)(bing)(bing)患者(zhe)，在(zai)服(fu)(fu)藥(yao)(yao)前(qian)后(hou)及(ji)服(fu)(fu)藥(yao)(yao)期(qi)觀(guan)察植(zhi)物(wu)神經(jing)系統(tong)的(de)(de)(de)(de)(de)(de)(de)(de)(de)有(you)(you)(you)(you)(you)(you)(you)(you)(you)關指(zhi)標(biao)，心電圖RR間(jian)期(qi)變(bian)(bian)化、Valsalva比(bi)值(zhi)、起立性(xing)(xing)(xing)(xing)(xing)低(di)(di)(di)血(xue)(xue)(xue)壓(ya)的(de)(de)(de)(de)(de)(de)(de)(de)(de)程度(du)(du)(du)、握(wo)拳(quan)試驗(yan)(yan)、神經(jing)傳導速(su)度(du)(du)(du)，服(fu)(fu)藥(yao)(yao)后(hou)這些指(zhi)標(biao)均(jun)有(you)(you)(you)(you)(you)(you)(you)(you)(you)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)。（8）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)內分(fen)(fen)(fen)泌代(dai)謝(xie)(xie)(xie)的(de)(de)(de)(de)(de)(de)(de)(de)(de)影(ying)響(xiang)(xiang)(xiang) 動(dong)(dong)(dong)物(wu)試驗(yan)(yan)證(zheng)(zheng)明(ming)金(jin)匱(kui)腎氣(qi)(qi)丸(wan)(wan)(wan)中(zhong)(zhong)附(fu)桂(gui)，能(neng)(neng)(neng)(neng)(neng)糾正大(da)(da)(da)劑(ji)(ji)量(liang)(liang)(liang)(liang)(liang)激素(su)(su)(su)(su)(su)所(suo)致(zhi)(zhi)小鼠(shu)(shu)(shu)體(ti)(ti)(ti)(ti)(ti)重減輕及(ji)虛弱或衰(shuai)竭狀態，說(shuo)明(ming)附(fu)桂(gui)八味(wei)丸(wan)(wan)(wan)有(you)(you)(you)(you)(you)(you)(you)(you)(you)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)垂體(ti)(ti)(ti)(ti)(ti)腎上(shang)(shang)(shang)腺(xian)皮(pi)(pi)質(zhi)(zhi)(zhi)(zhi)功(gong)能(neng)(neng)(neng)(neng)(neng)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，進一步(bu)研究本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)中(zhong)(zhong)生(sheng)藥(yao)(yao)發(fa)(fa)現丹(dan)皮(pi)(pi)、山茱萸及(ji)桂(gui)枝具有(you)(you)(you)(you)(you)(you)(you)(you)(you)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)腎上(shang)(shang)(shang)腺(xian)皮(pi)(pi)質(zhi)(zhi)(zhi)(zhi)激素(su)(su)(su)(su)(su)的(de)(de)(de)(de)(de)(de)(de)(de)(de)抑(yi)(yi)制(zhi)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，牡丹(dan)皮(pi)(pi)尚(shang)有(you)(you)(you)(you)(you)(you)(you)(you)(you)增(zeng)強(qiang)(qiang)(qiang)胰島素(su)(su)(su)(su)(su)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。也(ye)有(you)(you)(you)(you)(you)(you)(you)(you)(you)人(ren)(ren)應用(yong)(yong)(yong)(yong)(yong)(yong)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)治療支氣(qi)(qi)管喘(chuan)息患者(zhe)的(de)(de)(de)(de)(de)(de)(de)(de)(de)八味(wei)丸(wan)(wan)(wan)證(zheng)(zheng)病(bing)(bing)(bing)人(ren)(ren)。見(jian)到(dao)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)有(you)(you)(you)(you)(you)(you)(you)(you)(you)腎上(shang)(shang)(shang)腺(xian)皮(pi)(pi)質(zhi)(zhi)(zhi)(zhi)類固(gu)(gu)醇(chun)(chun)樣(yang)(yang)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。（9）改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)腎功(gong)能(neng)(neng)(neng)(neng)(neng)及(ji)利尿(niao)(niao)(niao)(niao)(niao)(niao)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong) 本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)以(yi)成(cheng)(cheng)(cheng)人(ren)(ren)用(yong)(yong)(yong)(yong)(yong)(yong)量(liang)(liang)(liang)(liang)(liang)10倍(bei)喂大(da)(da)(da)鼠(shu)(shu)(shu)1個月(yue)者(zhe)尿(niao)(niao)(niao)(niao)(niao)(niao)量(liang)(liang)(liang)(liang)(liang)增(zeng)加，尿(niao)(niao)(niao)(niao)(niao)(niao)中(zhong)(zhong)鈉離(li)子(zi)(zi)排泄(xie)(xie)增(zeng)加，鋅、鎂、鈣離(li)子(zi)(zi)排泄(xie)(xie)無(wu)明(ming)顯(xian)(xian)改(gai)(gai)(gai)(gai)(gai)(gai)變(bian)(bian)，血(xue)(xue)(xue)漿(jiang)中(zhong)(zhong)離(li)子(zi)(zi)均(jun)在(zai)正常范圍(wei)內，分(fen)(fen)(fen)析本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)其(qi)(qi)中(zhong)(zhong)地黃(huang)、澤瀉、茯苓和(he)(he)(he)附(fu)子(zi)(zi)均(jun)含(han)利尿(niao)(niao)(niao)(niao)(niao)(niao)成(cheng)(cheng)(cheng)分(fen)(fen)(fen)。本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)浸(jin)膏使(shi)(shi)IgG加速(su)型(xing)小鼠(shu)(shu)(shu)腎毒性(xing)(xing)(xing)(xing)(xing)腎炎血(xue)(xue)(xue)清(qing)白(bai)(bai)蛋(dan)白(bai)(bai)升(sheng)高(gao)(gao)(gao)，尿(niao)(niao)(niao)(niao)(niao)(niao)蛋(dan)白(bai)(bai)、血(xue)(xue)(xue)清(qing)尿(niao)(niao)(niao)(niao)(niao)(niao)素(su)(su)(su)(su)(su)氮降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)，同(tong)時(shi)(shi)可(ke)能(neng)(neng)(neng)(neng)(neng)通過(guo)(guo)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)血(xue)(xue)(xue)漿(jiang)過(guo)(guo)氧(yang)(yang)(yang)化脂(zhi)(zhi)(zhi)質(zhi)(zhi)(zhi)(zhi)的(de)(de)(de)(de)(de)(de)(de)(de)(de)含(han)量(liang)(liang)(liang)(liang)(liang)，改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)腎組織病(bing)(bing)(bing)變(bian)(bian)。對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)尿(niao)(niao)(niao)(niao)(niao)(niao)素(su)(su)(su)(su)(su)氮100～110mg/dl，腎功(gong)能(neng)(neng)(neng)(neng)(neng)全部喪失(shi)、四肢高(gao)(gao)(gao)度(du)(du)(du)水腫及(ji)乏力的(de)(de)(de)(de)(de)(de)(de)(de)(de)病(bing)(bing)(bing)人(ren)(ren)服(fu)(fu)本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)后(hou)可(ke)見(jian)癥(zheng)狀改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)，尿(niao)(niao)(niao)(niao)(niao)(niao)素(su)(su)(su)(su)(su)氮降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)至25mg/dl，腎功(gong)能(neng)(neng)(neng)(neng)(neng)逐漸恢(hui)復。（10）延緩衰(shuai)老(lao) 本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)不僅能(neng)(neng)(neng)(neng)(neng)使(shi)(shi)老(lao)化延緩，而(er)且能(neng)(neng)(neng)(neng)(neng)恢(hui)復精力。其(qi)(qi)機理，除(chu)(chu)強(qiang)(qiang)(qiang)心作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)甩外，可(ke)能(neng)(neng)(neng)(neng)(neng)還(huan)有(you)(you)(you)(you)(you)(you)(you)(you)(you)使(shi)(shi)全身細(xi)(xi)(xi)胞(bao)復活(huo)(huo)的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。有(you)(you)(you)(you)(you)(you)(you)(you)(you)人(ren)(ren)通過(guo)(guo)動(dong)(dong)(dong)物(wu)實(shi)(shi)驗(yan)(yan)，指(zhi)出本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)所(suo)以(yi)能(neng)(neng)(neng)(neng)(neng)“返老(lao)還(huan)童”，可(ke)能(neng)(neng)(neng)(neng)(neng)考慮本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)是(shi)以(yi)綜合性(xing)(xing)(xing)(xing)(xing)效率(lv)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)于(yu)(yu)機體(ti)(ti)(ti)(ti)(ti)，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)糖(tang)、蛋(dan)白(bai)(bai)質(zhi)(zhi)(zhi)(zhi)及(ji)脂(zhi)(zhi)(zhi)肪(fang)代(dai)謝(xie)(xie)(xie)等(deng)(deng)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)復雜地交織在(zai)一起，同(tong)時(shi)(shi)通過(guo)(guo)清(qing)除(chu)(chu)自(zi)(zi)(zi)(zi)由基(ji)(ji)(ji)和(he)(he)(he)過(guo)(guo)氧(yang)(yang)(yang)化物(wu)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，有(you)(you)(you)(you)(you)(you)(you)(you)(you)效地發(fa)(fa)揮抗(kang)衰(shuai)老(lao)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。（11）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)血(xue)(xue)(xue)壓(ya)的(de)(de)(de)(de)(de)(de)(de)(de)(de)影(ying)響(xiang)(xiang)(xiang) 本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)能(neng)(neng)(neng)(neng)(neng)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)高(gao)(gao)(gao)果糖(tang)誘發(fa)(fa)高(gao)(gao)(gao)血(xue)(xue)(xue)壓(ya)大(da)(da)(da)鼠(shu)(shu)(shu)血(xue)(xue)(xue)清(qing)去甲腎上(shang)(shang)(shang)腺(xian)上(shang)(shang)(shang)腺(xian)上(shang)(shang)(shang)腺(xian)素(su)(su)(su)(su)(su)含(han)量(liang)(liang)(liang)(liang)(liang)而(er)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)大(da)(da)(da)鼠(shu)(shu)(shu)血(xue)(xue)(xue)壓(ya)，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)自(zi)(zi)(zi)(zi)發(fa)(fa)性(xing)(xing)(xing)(xing)(xing)高(gao)(gao)(gao)血(xue)(xue)(xue)壓(ya)大(da)(da)(da)鼠(shu)(shu)(shu)（SHR）的(de)(de)(de)(de)(de)(de)(de)(de)(de)實(shi)(shi)驗(yan)(yan)表明(ming)，本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)明(ming)顯(xian)(xian)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)SHR的(de)(de)(de)(de)(de)(de)(de)(de)(de)血(xue)(xue)(xue)壓(ya)，降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)心臟左室壁、胸主動(dong)(dong)(dong)脈(mo)的(de)(de)(de)(de)(de)(de)(de)(de)(de)羥脯(fu)氨酸含(han)量(liang)(liang)(liang)(liang)(liang)，增(zeng)高(gao)(gao)(gao)尿(niao)(niao)(niao)(niao)(niao)(niao)激肽(tai)釋放酶的(de)(de)(de)(de)(de)(de)(de)(de)(de)排出，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)疾(ji)(ji)(ji)病(bing)(bing)(bing)表現改(gai)(gai)(gai)(gai)(gai)(gai)善(shan)(shan)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)。（12）對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)性(xing)(xing)(xing)(xing)(xing)激素(su)(su)(su)(su)(su)影(ying)響(xiang)(xiang)(xiang) 有(you)(you)(you)(you)(you)(you)(you)(you)(you)實(shi)(shi)驗(yan)(yan)顯(xian)(xian)示本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)能(neng)(neng)(neng)(neng)(neng)促進睪丸(wan)(wan)(wan)產(chan)生(sheng)睪丸(wan)(wan)(wan)酮的(de)(de)(de)(de)(de)(de)(de)(de)(de)作(zuo)(zuo)(zuo)(zuo)(zuo)(zuo)用(yong)(yong)(yong)(yong)(yong)(yong)，對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)10周齡(ling)大(da)(da)(da)鼠(shu)(shu)(shu)1630小時(shi)(shi)動(dong)(dong)(dong)情期(qi)Ⅱ，1100和(he)(he)(he)2300小時(shi)(shi)動(dong)(dong)(dong)情前(qian)期(qi)濾(lv)泡為實(shi)(shi)驗(yan)(yan)對(dui)(dui)(dui)(dui)(dui)(dui)(dui)(dui)象，本(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)(ben)方(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)(fang)在(zai)黃(huang)體(ti)(ti)(ti)(ti)(ti)生(sheng)成(cheng)(cheng)(cheng)素(su)(su)(su)(su)(su)升(sheng)高(gao)(gao)(gao)之前(qian) *** 排卵前(qian)濾(lv)泡分(fen)(fen)(fen)泌黃(huang)體(ti)(ti)(ti)(ti)(ti)酮，顯(xian)(xian)著(zhu)(zhu)降(jiang)(jiang)(jiang)(jiang)(jiang)(jiang)低(di)(di)(di)排卵前(qian)濾(lv)泡分(fen)(fen)(fen)泌雌二醇(chun)(chun)17β。

2.功(gong)能與主治 溫補(bu)腎陽。主治腎陽不足，腰膝酸痛，下肢冷感，少(shao)腹拘急，水腫，小便不利或小便頻數(shu)，陽痿，遺尿(niao)，尺脈微弱以及痰飲(yin)咳喘，消渴(ke)，腳(jiao)氣(qi)等證候。

3.毒(du)(du)性(xing)(xing)試驗(yan)(yan) 用附桂八味(wei)丸浸(jin)膏粉(fen)與5%阿拉伯(bo)膠溶液制(zhi)成的混懸液對大鼠作(zuo)慢性(xing)(xing)毒(du)(du)性(xing)(xing)試驗(yan)(yan)，以40、200、1000mg/kg劑量(liang)灌(guan)胃給藥(yao)。觀(guan)察6個月。結果對一(yi)般狀態、體重、飲水量(liang)、進食量(liang)、末梢血象均(jun)(jun)無影響。主要臟器在肉(rou)眼和(he)組(zu)織學上(shang)觀(guan)察也未見異常。于1000g/kg組(zu)大鼠的一(yi)些生化指標(biao)發生了變(bian)化，肺、腎(shen)、甲(jia)狀腺、腎(shen)上(shang)腺、垂體濕重均(jun)(jun)比對照(zhao)組(zu)低。結果指出，本方在常用量(liang)下從毒(du)(du)性(xing)(xing)學考(kao)慮是安全(quan)藥(yao)物，而大劑量(liang)有(you)使轉氨酶、脫氫酶和(he)中(zhong)性(xing)(xing)脂肪上(shang)升之疑。

4.不(bu)良反應 消(xiao)化(hua)系功能(neng)弱的(de)人(ren)服(fu)用本(ben)方可引(yin)起(qi)(qi)食欲減退或嘔(ou)吐、腹瀉(xie)，有(you)的(de)出現(xian)蕁(qian)麻疹。這主要由地(di)黃(huang)引(yin)起(qi)(qi)的(de)，以酒為引(yin)或許可以避免．另有(you)報道(dao)內服(fu)金匱(kui)腎氣(qi)丸(wan)引(yin)起(qi)(qi)過敏1例，表現(xian)為全身瘙癢，起(qi)(qi)紅(hong)色斑丘疹，伴陣發性心(xin)悸，EKG示竇性心(xin)律不(bu)齊，停藥(yao)后消(xiao)失，再服(fu)藥(yao)上述癥狀又出現(xian)，停藥(yao)后又消(xiao)失。

3.8附桂八味丸的適應證

1.（1）附(fu)桂八(ba)(ba)味(wei)(wei)丸(wan)(wan)(wan)隨(sui)(sui)證(zheng)加(jia)減(jian)(jian)治(zhi)(zhi)療(liao)(liao)(liao)(liao)慢性(xing)(xing)(xing)腎(shen)(shen)小(xiao)球腎(shen)(shen)炎(yan)(yan)患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)10例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，完全與(yu)基本(ben)(ben)(ben)緩解4例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，好(hao)轉3例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，取(qu)得(de)良好(hao)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)果(guo)(guo)(guo)。用(yong)(yong)(yong)薛氏(shi)加(jia)減(jian)(jian)本(ben)(ben)(ben)方(fang)(fang)治(zhi)(zhi)療(liao)(liao)(liao)(liao)6例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，能(neng)(neng)使(shi)浮腫(zhong)(zhong)漸退，尿(niao)(niao)(niao)量增多，尿(niao)(niao)(niao)蛋白(bai)消失或減(jian)(jian)少(shao)，腎(shen)(shen)功(gong)(gong)能(neng)(neng)改善。血(xue)(xue)(xue)壓降低(di)(di)。用(yong)(yong)(yong)本(ben)(ben)(ben)方(fang)(fang)治(zhi)(zhi)療(liao)(liao)(liao)(liao)腎(shen)(shen)性(xing)(xing)(xing)水腫(zhong)(zhong)12例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，其中(zhong)(zhong)3例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)配(pei)(pei)合(he)五皮飲內(nei)服(fu)，痊(quan)(quan)(quan)愈(yu)(yu)(yu)10例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，一(yi)般于服(fu)藥(yao)2周后(hou)(hou)見效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)。本(ben)(ben)(ben)方(fang)(fang)隨(sui)(sui)證(zheng)加(jia)減(jian)(jian)，熱(re)甚昏(hun)迷加(jia)用(yong)(yong)(yong)安宮牛黃丸(wan)(wan)(wan)或至寶丹，配(pei)(pei)合(he)西醫藥(yao)治(zhi)(zhi)療(liao)(liao)(liao)(liao)尿(niao)(niao)(niao)毒癥(zheng)(zheng)(zheng)39例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，生存18例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)。（2）慢性(xing)(xing)(xing)尿(niao)(niao)(niao)道炎(yan)(yan)：除少(shao)數(shu)病(bing)例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)加(jia)托里消毒飲或短期內(nei)配(pei)(pei)合(he)應用(yong)(yong)(yong)抗(kang)菌(jun)素(su)(su)外(wai)，其余病(bing)例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)均(jun)痊(quan)(quan)(quan)愈(yu)(yu)(yu)，且(qie)細胞學(xue)檢(jian)查陰性(xing)(xing)(xing)。（3）產(chan)后(hou)(hou)尿(niao)(niao)(niao)潴留：用(yong)(yong)(yong)本(ben)(ben)(ben)方(fang)(fang)或濟(ji)生腎(shen)(shen)氣(qi)丸(wan)(wan)(wan)加(jia)減(jian)(jian)治(zhi)(zhi)療(liao)(liao)(liao)(liao)41例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，若(ruo)產(chan)婦(fu)身體(ti)較(jiao)差，元氣(qi)不足，重加(jia)人(ren)(ren)參、北(bei)芪(qi)，因產(chan)后(hou)(hou)并發輕度(du)(du)感冒發熱(re)者(zhe)(zhe)(zhe)(zhe)先(xian)用(yong)(yong)(yong)辛(xin)平輕劑(ji)去其感冒，后(hou)(hou)以上(shang)(shang)(shang)方(fang)(fang)通利小(xiao)便，結(jie)果(guo)(guo)(guo)無(wu)(wu)有(you)(you)(you)(you)(you)(you)(you)不愈(yu)(yu)(yu)者(zhe)(zhe)(zhe)(zhe)。其中(zhong)(zhong)服(fu)藥(yao)1劑(ji)即(ji)通者(zhe)(zhe)(zhe)(zhe)23例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，占55.5%，連同服(fu)藥(yao)二(er)、三(san)劑(ji)小(xiao)便即(ji)通者(zhe)(zhe)(zhe)(zhe)12例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，約(yue)占整個(ge)病(bing)例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)的(de)(de)(de)85.5%。（4）前列(lie)腺(xian)增生：本(ben)(ben)(ben)方(fang)(fang)加(jia)滕龍湯效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)果(guo)(guo)(guo)滿(man)意，用(yong)(yong)(yong)該(gai)法治(zhi)(zhi)療(liao)(liao)(liao)(liao)65～81歲本(ben)(ben)(ben)病(bing)患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)均(jun)獲痊(quan)(quan)(quan)愈(yu)(yu)(yu)。另有(you)(you)(you)(you)(you)(you)(you)一(yi)報(bao)道對(dui)56例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)包(bao)括前列(lie)腺(xian)增生、膀胱頸部硬變、前列(lie)腺(xian)炎(yan)(yan)、神經性(xing)(xing)(xing)膀胱炎(yan)(yan)等前列(lie)腺(xian)綜合(he)征使(shi)用(yong)(yong)(yong)八(ba)(ba)味(wei)(wei)丸(wan)(wan)(wan)的(de)(de)(de)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)果(guo)(guo)(guo)，對(dui)主訴排(pai)尿(niao)(niao)(niao)困難者(zhe)(zhe)(zhe)(zhe)的(de)(de)(de)有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)率(lv)(lv)為(wei)46.9%，對(dui)尿(niao)(niao)(niao)頻及(ji)夜尿(niao)(niao)(niao)者(zhe)(zhe)(zhe)(zhe)有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)率(lv)(lv)為(wei)36%。（5）頑固性(xing)(xing)(xing)遺(yi)尿(niao)(niao)(niao)：1例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)女性(xing)(xing)(xing)，9歲，遺(yi)尿(niao)(niao)(niao)5年(nian)(nian)(nian)。早晚各服(fu)一(yi)丸(wan)(wan)(wan)，服(fu)10余丸(wan)(wan)(wan)后(hou)(hou)，夜尿(niao)(niao)(niao)減(jian)(jian)至1～2次，并能(neng)(neng)自醒，5天內(nei)僅(jin)遺(yi)尿(niao)(niao)(niao)一(yi)次。服(fu)至80丸(wan)(wan)(wan)，5年(nian)(nian)(nian)痼疾(ji)痊(quan)(quan)(quan)愈(yu)(yu)(yu)，2年(nian)(nian)(nian)內(nei)未有(you)(you)(you)(you)(you)(you)(you)復發。凡臨床(chuang)遇小(xiao)兒屬虛證(zheng)者(zhe)(zhe)(zhe)(zhe)，均(jun)投(tou)以附(fu)桂八(ba)(ba)味(wei)(wei)丸(wan)(wan)(wan)，已愈(yu)(yu)(yu)數(shu)例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)。（6）老年(nian)(nian)(nian)人(ren)(ren)尿(niao)(niao)(niao)失禁(jin)：對(dui)13例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)老年(nian)(nian)(nian)人(ren)(ren)尿(niao)(niao)(niao)失禁(jin)患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)用(yong)(yong)(yong)本(ben)(ben)(ben)方(fang)(fang)，每(mei)晨2丸(wan)(wan)(wan)，淡(dan)鹽水送服(fu)，10天一(yi)療(liao)(liao)(liao)(liao)程(cheng)(cheng)，四(si)個(ge)療(liao)(liao)(liao)(liao)程(cheng)(cheng)后(hou)(hou)6例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)痊(quan)(quan)(quan)愈(yu)(yu)(yu)，4例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)顯(xian)(xian)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)，2例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)好(hao)轉，無(wu)(wu)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)1例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，總有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)率(lv)(lv)92.3%。（7）老年(nian)(nian)(nian)性(xing)(xing)(xing) *** 炎(yan)(yan)；8例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)閉經8年(nian)(nian)(nian)以上(shang)(shang)(shang)的(de)(de)(de)老年(nian)(nian)(nian) *** 炎(yan)(yan)患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)，本(ben)(ben)(ben)方(fang)(fang)每(mei)日7.5g，分三(san)次服(fu)用(yong)(yong)(yong)，四(si)周后(hou)(hou)自覺(jue)癥(zheng)(zheng)(zheng)狀帶(dai)下(xia)8例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)中(zhong)(zhong)6例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)消失，2例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)減(jian)(jian)輕，腰(yao)痛(tong)，手足發麻，4全部消失，倦怠2例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)中(zhong)(zhong)1例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)消失。 *** 窺鏡檢(jian)查顯(xian)(xian)示 *** 壁及(ji) *** 子宮頸的(de)(de)(de)紅色斑點8例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)中(zhong)(zhong)6例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)消失，2例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)減(jian)(jian)輕，總有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)率(lv)(lv)100%。（8）男性(xing)(xing)(xing)不育癥(zheng)(zheng)(zheng)和 *** 減(jian)(jian)少(shao)癥(zheng)(zheng)(zheng)：男性(xing)(xing)(xing)不育癥(zheng)(zheng)(zheng) *** 濃度(du)(du)低(di)(di)于40×103/ml患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)用(yong)(yong)(yong)本(ben)(ben)(ben)方(fang)(fang)后(hou)(hou)52例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)中(zhong)(zhong)有(you)(you)(you)(you)(you)(you)(you)11例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)妊娠(shen)(shen)成功(gong)(gong)，55.8%見有(you)(you)(you)(you)(you)(you)(you)臨床(chuang)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)果(guo)(guo)(guo)，且(qie)多數(shu)在較(jiao)早期4～8周即(ji)出(chu)現效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)果(guo)(guo)(guo)，對(dui)其中(zhong)(zhong)27例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)（妊娠(shen)(shen)10例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，非妊娠(shen)(shen)17例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)）患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe) *** 濃度(du)(du)跟蹤結(jie)果(guo)(guo)(guo)顯(xian)(xian)示18例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)（55.6%） *** 濃度(du)(du)增加(jia)3倍以上(shang)(shang)(shang)，進一(yi)步分析 *** 輕度(du)(du)缺(que)(que)乏癥(zheng)(zheng)(zheng)（10～40×103/ml）的(de)(de)(de)患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)76.5%（13/17）臨床(chuang)有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)， *** 高度(du)(du)缺(que)(que)乏癥(zheng)(zheng)(zheng)（10×103/ml以下(xia)）只有(you)(you)(you)(you)(you)(you)(you)30%（3/10）臨床(chuang)有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)，從(cong)臨床(chuang)有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)的(de)(de)(de) *** 來(lai)看，本(ben)(ben)(ben)方(fang)(fang)對(dui) *** 運動率(lv)(lv)改善不明(ming)顯(xian)(xian)。治(zhi)(zhi)療(liao)(liao)(liao)(liao)前后(hou)(hou)周圍血(xue)(xue)(xue)中(zhong)(zhong)黃體(ti)生成素(su)(su)（LH）、催(cui)(cui)(cui)乳素(su)(su)（PRL）、睪丸(wan)(wan)(wan)酮（T）值幾乎(hu)無(wu)(wu)變化，有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)組卵泡 *** 素(su)(su)（FSH）值低(di)(di)下(xia)（P＜0.05），雌二(er)醇(chun)（E2）值上(shang)(shang)(shang)升(sheng)（P＜0.001）。結(jie)果(guo)(guo)(guo)顯(xian)(xian)示本(ben)(ben)(ben)方(fang)(fang)對(dui) *** 減(jian)(jian)少(shao)癥(zheng)(zheng)(zheng)初期是有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)的(de)(de)(de)，對(dui)造精機能(neng)(neng)、附(fu)屬腺(xian)或內(nei)分泌環(huan)境具(ju)有(you)(you)(you)(you)(you)(you)(you)直(zhi)接或間接的(de)(de)(de)作用(yong)(yong)(yong)。有(you)(you)(you)(you)(you)(you)(you)人(ren)(ren)用(yong)(yong)(yong)本(ben)(ben)(ben)方(fang)(fang)加(jia)服(fu)人(ren)(ren)參湯對(dui)該(gai)癥(zheng)(zheng)(zheng)也得(de)到(dao)良好(hao)的(de)(de)(de)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)果(guo)(guo)(guo)。（9）男子乳腺(xian)發育：對(dui)32例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)男性(xing)(xing)(xing) *** 發育癥(zheng)(zheng)(zheng)患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)，本(ben)(ben)(ben)方(fang)(fang)加(jia)減(jian)(jian)水煎服(fu)，每(mei)日1劑(ji)，60天后(hou)(hou)23例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)顯(xian)(xian)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)，7例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)好(hao)轉，無(wu)(wu)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)2例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，總有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)率(lv)(lv)93.7%。以病(bing)程(cheng)(cheng)短、年(nian)(nian)(nian)齡輕者(zhe)(zhe)(zhe)(zhe)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)果(guo)(guo)(guo)更(geng)佳(jia)。（10）勃(bo)起(qi)功(gong)(gong)能(neng)(neng)障(zhang)礙：治(zhi)(zhi)療(liao)(liao)(liao)(liao)該(gai)癥(zheng)(zheng)(zheng)有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)，對(dui)精神因素(su)(su)性(xing)(xing)(xing)療(liao)(liao)(liao)(liao)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)顯(xian)(xian)著，有(you)(you)(you)(you)(you)(you)(you)明(ming)顯(xian)(xian)的(de)(de)(de)增強勃(bo)起(qi)力(li)的(de)(de)(de)作用(yong)(yong)(yong)。以腎(shen)(shen)虛為(wei)主的(de)(de)(de)虛證(zheng)和瘦(shou)弱(ruo)型者(zhe)(zhe)(zhe)(zhe)有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)，對(dui)肥胖型不僅(jin)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)果(guo)(guo)(guo)不佳(jia)，且(qie)副作用(yong)(yong)(yong)多。（11）治(zhi)(zhi)婦(fu)女帶(dai)病(bing)：用(yong)(yong)(yong)本(ben)(ben)(ben)方(fang)(fang)加(jia)狗脊、菟絲子、肉蓯蓉(rong)治(zhi)(zhi)療(liao)(liao)(liao)(liao)腎(shen)(shen)氣(qi)虛寒、沖任衰弱(ruo)而(er)致(zhi)的(de)(de)(de)錦絲帶(dai)10例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，皆獲痊(quan)(quan)(quan)愈(yu)(yu)(yu)。（12）高催(cui)(cui)(cui)乳素(su)(su)血(xue)(xue)(xue)血(xue)(xue)(xue)癥(zheng)(zheng)(zheng)不孕(yun)癥(zheng)(zheng)(zheng)：對(dui)血(xue)(xue)(xue)催(cui)(cui)(cui)乳素(su)(su)＞30ng/ml的(de)(de)(de)女性(xing)(xing)(xing)不孕(yun)癥(zheng)(zheng)(zheng)患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)27例(li)(li)(li)(li)(li)(li)(li)(li)(li)(li)，投(tou)予本(ben)(ben)(ben)方(fang)(fang)每(mei)日2.5g～10g，3個(ge)月(yue)以上(shang)(shang)(shang)，有(you)(you)(you)(you)(you)(you)(you)18名患(huan)(huan)(huan)者(zhe)(zhe)(zhe)(zhe)血(xue)(xue)(xue)清催(cui)(cui)(cui)乳素(su)(su)下(xia)降，其中(zhong)(zhong)15名＜30ng/ml以下(xia)的(de)(de)(de)正常水平，有(you)(you)(you)(you)(you)(you)(you)12名妊娠(shen)(shen)，44.4%臨床(chuang)有(you)(you)(you)(you)(you)(you)(you)效(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)(xiao)，妊娠(shen)(shen)過(guo)程(cheng)(cheng)中(zhong)(zhong)也未見異常。

2.糖尿(niao)病(bing)(bing) 一般多是體力中等或中等以下(xia)，下(xia)腹部柔軟(ruan)無力，癥狀(zhuang)穩定，口渴(ke)輕。服(fu)藥后血(xue)糖常(chang)逐步(bu)下(xia)降，癥狀(zhuang)緩解。并(bing)認(ren)為約有60%～70%的糖尿(niao)病(bing)(bing)人(ren)適合(he)服(fu)用本方。對糖尿(niao)病(bing)(bing)性神經病(bing)(bing)變6例，服(fu)本丸提(ti)取劑，每日5～6g，共服(fu)3個月，按(an)綜合(he)性自覺癥狀(zhuang)好轉程度判定，有效、微效各2例。有報道本方加人(ren)參(can)對糖尿(niao)病(bing)(bing)患(huan)者有明(ming)顯療(liao)效，可減少胰島素注射量(liang)。

3.高血壓 本方加牛膝、車(che)前子適于本病陰損及陽而見(jian)腎(shen)陰虛(xu)損者，暈眩甚可加鉤藤、代褐(he)石(shi)、菊花、天麻，頭痛甚可加蔓(man)荊子、石(shi)決明(ming)、夏枯草、全蝎，項背強加葛根，動脈(mo)硬化重用丹皮(pi)，膽固醇高重用澤瀉，加首烏、草決明(ming)。用附桂八昧丸(wan)荊或(huo)湯劑(ji)治療(liao)高血壓11例，收(shou)到(dao)顯著(zhu)療(liao)效。

4.白(bai)(bai)內障 本(ben)病44例，大部分服用本(ben)方(fang)(fang)治(zhi)療(liao)，82只(zhi)眼睛中視力(li)上升(sheng)68只(zhi)，不變8只(zhi)，視力(li)上升(sheng)及視力(li)停止(zhi)下降的(de)(de)眼睛占93%。另有(you)284例不伴有(you)糖尿病、腎炎等疾患，亦無顯著的(de)(de)眼底和眼前(qian)部改變的(de)(de)本(ben)病患者。接(jie)受(shou)本(ben)方(fang)(fang)治(zhi)療(liao)，時間(jian)長短不一(yi)，總有(you)效率(lv)為72.2%，568只(zhi)患眼的(de)(de)總有(you)效率(lv)為81.4%，可見(jian)本(ben)方(fang)(fang)對改善(shan)和阻止(zhi)老年性白(bai)(bai)內障的(de)(de)發展有(you)良好療(liao)效。亦有(you)報道認(ren)為該(gai)方(fang)(fang)可使患者眼球彈(dan)性增加，晶體的(de)(de)白(bai)(bai)色混濁(zhuo)減(jian)退，視力(li)改善(shan)。越早期(qi)給藥，療(liao)效也越好，并觀(guan)察(cha)到本(ben)方(fang)(fang)用于老花眼治(zhi)療(liao)也得到良好效果。

5.支氣(qi)管喘(chuan)(chuan)息(xi)癥 從中(zhong)醫(yi)來(lai)看相當于咳嗽、哮喘(chuan)(chuan)、喘(chuan)(chuan)息(xi)等癥。一(yi)組接(jie)受西醫(yi)治(zhi)療的(de)107例(li)氣(qi)管炎(yan)喘(chuan)(chuan)息(xi)患者(zhe)加中(zhong)藥治(zhi)療，原則(ze)上用(yong)(yong)(yong)中(zhong)藥提取(qu)物5g分(fen)早、晚兩(liang)次服用(yong)(yong)(yong)。其(qi)中(zhong)八味丸證占(zhan)31.8%（此(ci)證病(bing)例(li)西醫(yi)常用(yong)(yong)(yong)腎(shen)上腺皮質(zhi)類固(gu)醇），應用(yong)(yong)(yong)方有(you)效率(lv)為76%。本(ben)方驗例(li)：一(yi)日(ri)2次，每(mei)日(ri)1丸（每(mei)丸9g）服至(zhi)100丸，哮喘(chuan)(chuan)停止發(fa)作，余癥消失，又自服200丸左(zuo)右以鞏(gong)固(gu)療效，隨訪3年，未復發(fa)。近年來(lai)有(you)人用(yong)(yong)(yong)本(ben)方治(zhi)療難治(zhi)性哮喘(chuan)(chuan)，由于哮喘(chuan)(chuan)反復發(fa)作使(shi)(shi)肺(fei)腎(shen)宣降，納氣(qi)功能下降，導(dao)致氣(qi)血兩(liang)虛(xu)，進(jin)而容易亡陽(yang)，使(shi)(shi)用(yong)(yong)(yong)治(zhi)療腎(shen)虛(xu)證的(de)本(ben)方后有(you)明(ming)顯(xian)療效，與其(qi)他漢方藥聯合使(shi)(shi)用(yong)(yong)(yong)得到(dao)65%本(ben)疾病(bing)的(de)改善率(lv)。

6.腹水(shui)(shui) 22例晚期(qi)血吸蟲(chong)病腹水(shui)(shui)久治(zhi)不愈患者，有(you)腎功能損(sun)害，尿檢(jian)有(you)蛋白(bai)、管型及(ji)紅、白(bai)細(xi)胞。先服附桂八味丸(wan)（每日(ri)30g分服）以固本(ben)(ben)，后用撒利汞（每日(ri)注射1支）以治(zhi)標，再服本(ben)(ben)方(fang)以培本(ben)(ben)，交互作用，腹水(shui)(shui)全(quan)部消退。腹水(shui)(shui)消除(chu)后，有(you)17例轉(zhuan)銻劑治(zhi)療，其中(zhong)15例完成(cheng)療程。酒石(shi)酸銻劑治(zhi)療血吸蟲(chong)病引(yin)起的(de)腎損(sun)害用本(ben)(ben)方(fang)有(you)效，治(zhi)療5例均獲良好效果，有(you)助于血吸蟲(chong)病患者完成(cheng)銻劑的(de)治(zhi)療。

7.浮腫(zhong) 使用本方每日二(er)次(ci)。每次(ci)9g，治療(liao)水腫(zhong)12例(li)，其(qi)中3例(li)并有(you)下(xia)肢水腫(zhong)，配合五皮飲內(nei)服(fu)(fu)，結果治愈10例(li)，無效2例(li)（合并鉤(gou)蟲病、貧血及血吸蟲病腹水），治療(liao)時間最(zui)長者90日，最(zui)短者21日。一般病例(li)服(fu)(fu)藥(yao)2周后癥狀減輕(qing)，尿量增加，水腫(zhong)漸次(ci)消(xiao)退。

8.腰痛(tong) 對55～80歲慢(man)性腰痛(tong)患者(zhe)12例，給服(fu)八(ba)味丸浸膏顆(ke)粒5g，一(yi)日一(yi)次，飯前服(fu)用連服(fu)2～8周，有效率達83.3%。另對主訴(su)腰痛(tong)的患者(zhe)10例，給予本方(fang)，觀察其鎮(zhen)痛(tong)效果及對內分泌功能的影(ying)響，疼痛(tong)緩(huan)解(jie)有效率為60%。

9.骨質疏松(song) 對門診絕經期以微量(liang)密度測定(ding)（MD）法篩選4分以上的骨質疏松(song)患者27例(li)，用本方提(ti)取劑加VD2治療6個月、12個月后，27例(li)中(zhong)19例(li)MD總分降低，其中(zhong)6例(li)降至3分以下的正常范圍，21例(li)（78%）骨量(liang)增加。

10.肝(gan)硬化(hua)伴腓(fei)腸肌(ji)痙攣(luan) 對(dui)每周痙攣(luan)發作(zuo)(zuo)超過1次以(yi)上(shang)(shang)的26例(li)(li)(li)患(huan)者甩本(ben)方每日7.5g，連(lian)用四(si)周以(yi)上(shang)(shang)，甩藥1周后(hou)(hou)9例(li)(li)(li)消(xiao)失，4周后(hou)(hou)16例(li)(li)(li)消(xiao)失，10例(li)(li)(li)改善，全部有(you)效。其中(zhong)隨機取5例(li)(li)(li)有(you)效患(huan)者作(zuo)(zuo)振(zhen)動覺閾(yu)值檢查，結果顯(xian)示用藥后(hou)(hou)均(jun)有(you)明(ming)顯(xian)改善。

11.痛(tong)風性關(guan)節(jie)(jie)性關(guan)節(jie)(jie)炎(yan)(yan) 15例(li)(li)患者(zhe)用本方煎劑加減每日一次，二周以上，4例(li)(li)急性關(guan)節(jie)(jie)炎(yan)(yan)者(zhe)均好轉，11例(li)(li)慢性關(guan)節(jie)(jie)炎(yan)(yan)者(zhe)9例(li)(li)好轉，2例(li)(li)無(wu)效(xiao)，總有效(xiao)率86.66%。

12.蕁麻疹 用(yong)本方(fang)(fang)和(he)(he)自制風疹酒（面(mian)堿15g、冰片5g，白(bai)酒50ml）外(wai)用(yong)，治(zhi)本病急(ji)慢(man)性患者10例(li)(li)，均獲痊愈(yu)。治(zhi)慢(man)性蕁麻疹服(fu)丸藥時用(yong)小(xiao)米湯送服(fu)可(ke)提(ti)高(gao)療(liao)效(xiao)。 此外(wai)附桂八味丸治(zhi)療(liao)老年變形性膝關節(jie)病4例(li)(li)全(quan)部(bu)好轉，治(zhi)骨(gu)結(jie)核(he)15例(li)(li)13例(li)(li)治(zhi)愈(yu)，2例(li)(li)好轉，本方(fang)(fang)還通過意(yi)志(zhi)激活和(he)(he)抗焦躁兩種相反的趨精神作用(yong)，治(zhi)療(liao)輕中度意(yi)志(zhi)減(jian)退患者有(you)(you)明(ming)顯療(liao)效(xiao)。對尿崩癥(zheng)、腎病綜合(he)征、腎小(xiao)球腎炎、視(shi)網膜出血、青(qing)光眼、肺結(jie)核(he)、眼瞼抽搐癥(zheng)、貧血、失眠(mian)癥(zheng)、唾涎癥(zheng)、長(chang)期(qi)低熱、慢(man)性腹褥等均有(you)(you)一(yi)定療(liao)效(xiao)，合(he)芍藥甘(gan)草湯治(zhi)療(liao)坐骨(gu)神經痛(tong)(tong)也有(you)(you)明(ming)顯效(xiao)果，與西藥心痛(tong)(tong)定、硫氮窧酮合(he)并治(zhi)療(liao)心絞痛(tong)(tong)可(ke)顯著減(jian)少(shao)(shao)發作次數(shu)，減(jian)少(shao)(shao)硝酸甘(gan)油(you)含服(fu)量。

3.9注意事項

消(xiao)化功能弱的人服用本方(fang)可引起食欲(yu)減退或嘔吐、腹(fu)瀉，有的出現蕁麻疹。

3.10附桂八味丸的用法用量

每(mei)服(fu)9g，日2～3次，溫開(kai)水或淡鹽湯(tang)送服(fu)；或做(zuo)湯(tang)劑(ji)，水煎服(fu)，用量(liang)按原方比例(li)酌減或作沖劑(ji)、散劑(ji)。片：一(yi)(yi)次6片，口服(fu)，一(yi)(yi)日2次。口服(fu)液(ye)：口服(fu)一(yi)(yi)次1支，一(yi)(yi)日2次。膠囊劑(ji)：口服(fu)，一(yi)(yi)次5粒，一(yi)(yi)日2次。

3.11專家點評

加減漏蘆湯簡介

目(mu)錄(lu)1拼音2處(chu)方3功能主治4加減(jian)漏蘆(lu)湯(tang)的用法用量5摘錄(lu)附：1古籍中的加減(jian)漏蘆(lu)湯(tang) 1拼音 jiā jiǎn lòu lú tāng

2處方漏蘆30克(ke)(ke)(ke)，劉寄奴30克(ke)(ke)(ke)，公英30克(ke)(ke)(ke)，地丁30克(ke)(ke)(ke)，雙花30克(ke)(ke)(ke)，連翹30克(ke)(ke)(ke)，柴胡13克(ke)(ke)(ke)，海藻15克(ke)(ke)(ke)，元參12克(ke)(ke)(ke)，香附12克(ke)(ke)(ke)，大貝12克(ke)(ke)(ke)，皂刺10克(ke)(ke)(ke)。

3功能主治理(li)氣(qi)活血，軟堅散結，疏肝解郁化痰。主氣(qi)滯痰凝(ning)結。

4加減漏蘆湯的用法用量水(shui)煎服，每(mei)日1劑，日服4次(ci)。

5摘錄王法昌方

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